首页|腹腔镜手术联合GnRH-a治疗子宫内膜异位症近期疗效及预后复发影响因素分析

腹腔镜手术联合GnRH-a治疗子宫内膜异位症近期疗效及预后复发影响因素分析

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目的:分析腹腔镜手术联合促性腺激素释放激素类似物(Gonadotropin releasing hormone analogues,GnRH-a)治疗子宫内膜异位症(Endometriosis,EMS)近期疗效及预后复发情况.方法:回顾性收集2021年 3 月至2022年 4 月于本院就诊的EMS患者 88 例作为研究对象.按照治疗方案的不同将患者分为对照组(腹腔镜手术治疗,42例)和观察组(腹腔镜手术+GnRH-a治疗,46例).对比两组近期疗效、预后复发率以及影响观察组预后的因素.结果:观察组临床疗效高于对照组,复发率低于对照组(P<0.05).观察组中,经二元Logistic回归分析结果显示,发病年龄、美国生育学会(American fertility society,AFS)的EMS分期、术前痛经史、术前孕次、术前产次、宫腔操作既往史是观察组复发率的影响因素(P<0.05).结论:腹腔镜手术联合GnRH-a治疗EMS近期疗效理想,但仍存在一定复发率,发病年龄、AFS的EMS分期、术前痛经史、术前孕次、术前产次、宫腔操作既往史是影响其复发的因素,临床及时对此给予针对性干预有利于预后改善.
Analysis of the factors influencing the short-term efficacy and prognosis of endometriosis treated by laparoscopic surgery combined with GnRH-a
Objective:To analyze the short-term efficacy and prognosis of patients with Endometriosis(EMS)treated by laparoscopic surgery combined with Gonadotropin releasing hormone analogues(GnRH-a).Methods:A total of 88 patients with EMS who visited our hospital from March 2021 to April 2022 were retrospectively collected.Patients were divided into control group(laparoscopic surgery,42 cases)and observation group(laparoscopic surgery +GnRH-a treatment,46 cases)according to different treatment plans.The short-term efficacy,recurrence rate and factors affecting the prognosis of the observation group were compared between the two groups.Results:The clinical efficacy of the observation group was higher than that of the control group,and the recurrence rate was lower than that of the control group(P<0.05).In the observation group,binary Logistic regression analysis showed that age of onset,American fertility society,EMS stage,dysmenorrhea history before operation,pregnancy time before operation,delivery time before operation and history of uterine operation were the factors affecting the recurrence rate of the observation group(P<0.05).Conclusion:Laparoscopic surgery combined with GnRH-a has ideal short-term efficacy in the treatment of EMS,but there is still a certain recurrence rate.Age of onset,EMS stage of AFS,preoperative dysmenorrhea history,preoperative pregnancy and delivery times,and previous history of uterine operation are factors that affect its recurrence.Timely targeted clinical intervention is needed to improve prognosis.

Laparoscopic surgeryGnRH-aEMSShort-term efficacyPrognostic recurrence

袁婷婷、吴鹤立、潘学景、卢秋阳

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南阳市中心医院妇产科,河南 南阳 473000

腹腔镜手术 GnRH-a EMS 近期疗效 预后复发

2024

四川生理科学杂志
四川省生理科学会

四川生理科学杂志

影响因子:0.575
ISSN:1671-3885
年,卷(期):2024.46(3)
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