首页|食管鳞癌中Versican、NF-κB和MMP-9的表达及其与临床病理特征的关系

食管鳞癌中Versican、NF-κB和MMP-9的表达及其与临床病理特征的关系

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目的:观察食管鳞癌组织中多功能蛋白聚糖(Versican)、核因子-κB(Nuclear factor-kappa B,NF-κB)和基质金属蛋白酶-9(Matrix metalloproteinase-9,MMP-9)蛋白及 mRNA 的表达及其与临床病理特征的关系.方法:采用免疫组化及原位杂交方法检测 47 例食管鳞癌组织及癌旁正常食管黏膜组织中 Versican、NF-κB 和 MMP-9 蛋白及 mRNA 的表达情况,并分析其与临床病理特征的关系及三者的相关性.结果:食管鳞癌组织中 Versican、NF-κB 和 MMP-9 蛋白及 mRNA 表达的阳性率均明显高于癌旁正常食管黏膜组织中的表达(P＜0.05);食管鳞癌组织中 Versican、NF-κB 和 MMP-9 蛋白及 mRNA 的高表达与浸润深度越深、淋巴结有转移、TNM 分期越晚均有关(P＜0.05),与性别、年龄、组织分级均无关;食管鳞癌组织中,Versican、NF-κB 和 MMP-9 三者在蛋白及 mRNA 水平的表达均呈正相关(P＜0.05).结论:Versican、NF-KB 和 MMP-9 在食管鳞癌中的高表达与肿瘤的生成、浸润及转移密切相关,并且三者具有相关性,为我们进一步探索食管鳞癌浸润转移的潜在机制奠定了基础.
Expression of Versican,NF-κB and MMP-9 in esophageal squamous cell carcinoma and their relationship with clinicopathological characteristics
Objective:To observe the expressions of Versican,nuclear factor-kappa B(NF-κB)and matrix metalloproteinase-9(MMP-9)protein and mRNA in esophageal squamous cell carcinoma tissue and their relationship with clinicopathological characteristics.Methods:Immunohistochemistry and in situ hybridization were used to detect the expressions of Versican,NF-κB and MMP-9 protein and mRNA in 47 cases of esophageal squamous cell carcinoma tissues and paired adjacent normal esophageal mucosal tissues,and their correlations with clinicopathological characteristics were analyzed.The relationship and the correlation between the three molecules were analyzed.Results:The positive rates of Versican,NF-κB,and MMP-9 protein and mRNA expression in esophageal squamous cell carcinoma tissues were significantly higher than that in paired normal esophageal mucosal tissue adjacent to cancer(P<0.05);The high expression of Versican,NF-κB,MMP-9 protein and mRNA in esophageal squamous cell carcinoma tissues was related to deeper invasion depth,lymph node metastasis,and later TNM stage(P<0.05),but was not related to gender,age,and tissue grade;in esophageal squamous cell carcinoma tissue,the protein and mRNA levels of Versican and NF-κB,Versican were all positively correlated(P<0.05).Conclusion:The high expression of Versican,NF-κB and MMP-9 in esophageal squamous cell carcinoma is closely related to tumor formation,invasion and metastasis,and the three molecules are correlated,which lays the foundation for us to further explore the potential mechanisms of esophageal squamous cell carcinoma invasion and metastasis.

Esophageal squamous cell carcinomaVersicanNF-κBMMP-9pathological characteristicsInfiltration and metastasis

王佳佳、徐小艳、王军、徐宪伟、闫琛、邢晨菊、吕玉红、姜黄

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河南中医药大学第五临床医学院,郑州人民医院病理科,河南 郑州 450000

河南中医药大学第五临床医学院,郑州人民医院妇科,河南 郑州 450000

郑州市中医院病理科,河南 郑州 450000

食管鳞癌 Versican NF-κB MMP-9 病理特征 浸润转移

河南省医学科技攻关计划联合共建项目(2021)

LHGJ20200706

2024

四川生理科学杂志
四川省生理科学会

四川生理科学杂志

影响因子：0.575
ISSN：1671-3885
年,卷(期)：2024.46(4)
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