Efficacy evaluation of bifidobacterium tetrad live capsule combined with pancreatic enzyme enteric-coated capsule in patients with intestinal dysfunction of moderate to severe non-alcoholic fatty liver disease
Objective:To study the effect of bifidobacterium tetrad live capsule combined with pancreatic enzyme enteric capsule in the treatment of moderate to severe non-alcoholic fatty liver disease(NAFLD)patients with intestinal dysfunction.Methods:One hundred and fifty-four patients with moderate to severe NAFLD intestinal dysfunction admitted to our hospital from January 2021 to June 2023 were selected as the study subjects.They were randomly divided into a control group and a combination group using a random number table method,with 77 patients in each group.The control group was treated with pancreatin enteric coated capsules,and on the basis of the control group,the combination group was treated with Bifidobacterium quadruplex viable capsules.Compare the clinical efficacy,intestinal symptom relief time,liver function and lipid metabolism indicators,intestinal microbiota(Bifidobacterium,Lactobacillus,Escherichia coli,Enterococcus),and lipid peroxidation indicators between the two groups.Results:The total clinical effective rate of the combined group is significantly higher than that of the control group(P<0.05).After treatment,the relief time of symptoms such as bowel ringing,urgency,abdominal distension,anal discharge,diarrhea,fecal mucus,and abdominal pain in the combination group was significantly shorter than that in the control group(P<0.05).The levels of total cholesterol(TC),glutamic oxaloacetic transaminase(GOT),triglycerides(TG),and alanine transaminase(ALT)in the combination group were significantly lower than those in the control group(P<0.05).The levels of Escherichia coli and Enterococcus in the combined group were significantly reduced,while the levels of Bifidobacterium and Lactobacillus were significantly higher than those in the control group(P<0.05).The levels of malondialdehyde(MDA)in the combination group were significantly lower than those in the control group,while the levels of superoxide dismutase(SOD)and total glutathione(T-GSH)were significantly higher than those in the control group(P<0.05).Conclusion:Bifidobacterium tetrad live capsule combined with pancreatic enzyme enteric-coated capsule has significant effect in the treatment of intestinal dysfunction of moderate and severe NAFLD,which can alleviate symptoms,inhibit lipid peroxidation,maintain normal intestinal microecological environment,promote intestinal function recovery and enhance liver function.
NAFLDBifidobacteriumQuadruple Viable CapsulePancreatic enzyme enteric-coated capsuleIntestinal function
NETL
NSTL
万方数据
维普
