Effects of Bifidobacterium tetrad viable tablets combined with montmorillonite powder on intestinal mucosal barrier and serum inflammatory factors in children with diarrhea
Objective:To study the effects of bifidobacterium tetrad viable tablets plus montmorillonite powder on intestinal mucosal barrier and serum inflammatory factors in children with diarrhea.Methods:204 children with diarrhea diagnosed in our hospital(March 2022 to March 2023)were divided into study group and reference group with 102 cases each.The reference group was treated with montmorillonite powder,and the study group was treated with bifidobacterium tetrad viable tablets on the basis of Montmorillonite.Comparing the clinical efficacy,intestinal mucosal barrier function indexes,tumor necrosis factor-α(TNF-α),vasoactive intestinal polypeptide(VIP),C-reactive protein(CRP),motilin(MTL),interleukin-10(IL-10),somatostatin(SS),interferon-γ(IFN-γ)and incidence of adverse reactions between the two groups.Results:The total effective rate of the study group was higher than that of the reference group(P<0.05).After treatment,the levels of D-lactic acid,diamine oxidase and endotoxin in the study group were lower than those in the control group(P<0.05);After treatment,IL-10 and IFN-γ in the study group were higher than those in the reference group,while MTL,VIP,SS,TNF-α and CRP were lower than those in the reference group(P<0.05).After treatment,there was no significant difference in the total incidence of adverse reactions between the study group and the reference group(P>0.05).Conclusion:The combined treatment is effective,can effectively improve the intestinal mucosa of children,reduce inflammation,and less adverse reactions,high safety.
Bifidobacterium tetrad viable tabletMontmorillonite powderChildren with diarrheaCurative effect
NETL
NSTL
万方数据
维普
