法莫替丁辅助治疗对急性肠胃炎患者症状、胃肠道功能和炎症的影响
Effects of famotidine as adjuvant therapy on symptoms,gastrointestinal function,and inflammation in patients with acute gastroenteritis
段方方 1沈桂佳 2曹慧3
作者信息
- 1. 湖口县中医院,江西 湖口 332500
- 2. 九江学院附属医院,江西 九江 332000
- 3. 湖口县人民医院,江西湖口 332500
- 折叠
摘要
目的:研究法莫替丁辅助治疗对急性肠胃炎患者症状、胃肠道功能和炎症的影响.方法:选取 2021 年 8 月至 2023 年 8 月期间收治的急性肠胃炎患者 60 例,采用随机数字表法分为对照组和观察组(n=30).对照组给予肌肉注射盐酸甲氧氯普胺 10 mg,观察组在对照组基础上给予静脉滴注法莫替丁 20 mg治疗,比较两组胃肠道功能及症状改善情况,治疗前及治疗 3 d后应用酶联免疫吸附(Enzyme-linked immunosorbent assay,ELISA)法测定白细胞介素-6(Interleukin-6,IL-6)、超敏C-反应蛋白(High-sensitivity C-reactive protein,hs-CRP)水平,以个体生活质量评估量表(The Quality of Life Scale,QOL)、舒适度量表(General Comfort Questionnaire,GCQ)进行评分.结果:观察组腹痛、腹泻及呕吐改善时间均低于对照组(P＜0.05);治疗后观察组血清IL-6、hs-CRP水平均低于对照组(P＜0.05);观察组总有效率(96.67%)高于对照组(80.00%)(P＜0.05);治疗后观察组QOL、GCQ评分均高于对照组(P＜0.05).结论:法莫替丁辅助治疗急性肠胃炎患者可以促进其临床症状及胃肠道功能恢复,降低炎症因子水平,提高临床疗效,有效改善生活质量并提高舒适度.
Abstract
Objective:To study the effects of famotidine as adjuvant therapy on symptoms,gastrointestinal function,and inflammation in patients with acute gastroenteritis.Methods:Sixty patients with acute gastroenteritis admitted between August 2021 and August 2023 were randomly divided into a control group and an observation group(n=30)using a random number table method.The control group was given an intramuscular injection of metoclopramide hydrochloride 10 mg,while the observation group was given an intravenous infusion of famotidine 20 mg based on the treatment of the control group.The improvements in gastrointestinal function and symptoms were compared between the two groups.The levels of inflammatory factors,including interleukin-6(IL-6)and high-sensitivity C-reactive protein(hs-CRP)were measured by enzyme-linked immunosorbent assay(ELISA)before treatment and after 3 days of treatment.The Quality of Life Scale(QOL)scores,the General Comfort Questionnaire(GCQ)scores,and clinical efficacy were compared between the two groups.Results:The improvement time of abdominal pain,diarrhea,and vomiting in the observation group was shorter than that in the control group(P<0.05).After treatment,serum IL-6 and hs-CRP levels in the observation group were lower than those in the control group(P<0.05).The total effective rate of the observation group(96.67%)was higher than that of the control group(80.00%)(P<0.05).After treatment,the QOL scores and GCQ scores of the observation group were higher than those of the control group(P<0.05).Conclusion:Famotidine as adjuvant therapy can promote relief of clinical symptoms and recovery of gastrointestinal function in patients with acute gastroenteritis,lower the levels of inflammatory factors,improve clinical efficacy,effectively improve the quality of life,and enhance comfort level.
关键词
法莫替丁/急性肠胃炎/临床症状/胃肠道功能/炎症因子Key words
Famotidine/Acute gastroenteritis/Clinical symptom/Gastrointestinal function/Inflammatory factor引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据