Effect of daglipzin assisted with sacubitril valsartan on patients with coronary heart disease after interventional therapy
Objective:To analyze the effects of daglizin assisted by sacubitril valsartan on cardiac function and serum inflammatory factors in patients with percutaneous coronary intervention(PCI).Methods:A total of 150 PCI patients admitted to Zhenping Second People's Hospital from February 2022 to February 2023 were randomly divided into study group(75 cases)and control group(75 cases).The control group was treated with sacubitril valsartan,and the study group was treated with dagliprazin assisted sacubitril valsartan.After 3 months of treatment,the efficacy and incidence of major adverse cardiac events(MACE)were compared between the two groups.stroke volume(SV),left ventricular ejection fraction(LVEF)and cardiac output(CO)were used to evaluate the cardiac function of patients before and after treatment.Stroke volume(SV),left ventricular ejection fraction(LVEF)and cardiac output(CO)were used to evaluate the cardiac function of patients before and after treatment.The levels of Nitricoxide(NO),vascular endothelial growth factor(VEGF),Endothelin-1(ET-1)and homocysteine(Hcy),C-reactive protein(CRP),interleukin-6(IL-6),Tumor necrosis factor-α(TNF-α)were used to evaluate the vascular endothelial function and inflammatory status of patients.Results:The total effective rate of the study group was 94.67%higher than that of the control group 81.33%.After treatment,the SV,LVEF and CO of the study group were higher than those of the control group(P<0.05).After treatment,ET-1 of the study group was lower than that of the control group,and NO,VEGF,Hcy,TNF-α,CRP and IL-6 were higher than that of the control group(P<0.05).After treatment,the incidence of MACE in the study group was 4.00%lower than that in the control group 14.67%(P<0.05).Conclusion:Daglipzin assisted with sacubitril valsartan has obvious effect on recovery after PCI,which is beneficial to the improvement of patients'cardiac function,and can reduce the inflammatory response and MACE events.
NETL
NSTL
万方数据
维普
