Predictive efficiency of coagulation function for early rebleeding in patients with cirrhosis and esophageal variceal bleeding after endoscopy
Objective:To analyze the predictive efficiency of coagulation function for early rebleeding in patients with cirrhosis and esophageal variceal bleeding after endoscopy.Methods:A total of 64 patients with cirrhosis and esophageal variceal bleeding undergoing endoscopy in the hospital were enrolled between June 2021 and June 2023.According to presence or absence of postoperative rebleeding,they were divided into bleeding group(31 cases)and non-bleeding group(33 cases).The coagulation four indices[thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)]were compared between the two groups at 1 day,5 days and 7 days after surgery,and their predictive value for early rebleeding after endoscopy was analyzed by receiver operating characteristic(ROC)curves at 1 day after surgery.Results:At 1 day after surgery,PT,APTT and TT in bleeding group were longer than those in non-bleeding group,and FIB level was lower than that in non-bleeding group(P<0.05).At 5 days after surgery,PT,APTT and TT in bleeding group were longer than those in non-bleeding group,and FIB level was lower than that in non-bleeding group(P<0.05).At 7 days after surgery,PT and TT in bleeding group were longer than those in non-bleeding group,FIB level was lower than that in non-bleeding group(P<0.05),but there was no significant difference in APTT between the two groups(P>0.05).ROC curves analysis showed that area under the curve(AUC),sensitivity and specificity of PT,APTT,TT and FIB for predicting early rebleeding after endoscopy were(0.679,0.761,0.754,0.743),(72.73%,66.67%,75.00%,79.17%)and(64.29%,75.00%,72.22%,70.00%),respectively(P<0.05).Conclusion:Coagulation function has predictive value for early rebleeding in patients with cirrhosis and esophageal variceal bleeding after endoscopy,which can be applied in early evaluation of rebleeding risk.
NETL
NSTL
万方数据
维普
