Investigation of distant metastasis,prognosis and survival of patients with nasopharyngeal carcinoma after radical chemoradiotherapy and analysis of influencing factors
Objective:To analyze the prognosis and predictors of survival in patients with distant metastatic nasopharyngeal carcinoma after radical radiotherapy.Methods:The clinical data of 108 patients with nasopharyngeal carcinoma admitted to our hospital from March 2015 to October 2020 were retrospectively analyzed.All patients were treated with radical radiotherapy and chemotherapy at initial diagnosis.Follow-up data of patients were recorded,remote metastasis and survival in 3 years were analyzed,and the risk factors affecting the prognosis and survival of patients were analyzed.Results:Up to the end of follow-up,95(87.96%)of 108 patients had distant metastasis,the median metastasis time was 14.42±2.62 months,and the most common metastatic sites were bone metastasis,lung metastasis and mediastinal lymph node metastasis.The median survival time of 108 patients was 13.41±4.81 months,and the survival rate was 26.31%.Of the 95 patients with distant metastasis,4 patients only received nutritional intervention.6 patients received metastatic palliative radiotherapy;48 cases received systemic chemotherapy alone;37 cases received systemic adjuvant chemotherapy and local palliative radiotherapy.N stage at initial diagnosis,weeks of chemotherapy after metastasis and site of metastasis were independent risk factors for survival of patients with distant metastatic nasopharyngeal carcinoma after radical radiotherapy(P<0.05).Conclusion:The N stage at initial diagnosis,the number of weeks of chemotherapy after metastasis and the site of metastasis are all predictors of prognosis and survival of patients with distant metastasis of nasopharyngeal carcinoma after radical radiotherapy.Reasonable intervention of high-risk patients with combined risk factors is conducive to improving the survival rate of patients with distant metastasis after treatment.
NETL
NSTL
万方数据
维普
