Relationship between T lymphocyte and EGFR and clinical features and prognosis of lung adenocarcinoma
Objective:To investigate the relationship of T lymphocyte subsets and Epidermal growth factor receptor(EGFR)with clinical features and prognosis of lung adenocarcinoma.Methods:72 patients with lung adenocarcinoma admitted to our hospital from October 2019 to October 2022 were selected as the study objects.The expression levels of CD4+,CD8+ and EGFR in pathological tissues and adjacent tissues of lung adenocarcinoma were compared between the two groups,and their relationship with clinical features was analyzed.The value of CD4+,CD8+ and EGFR expression levels in the diagnosis of lung adenocarcinoma was evaluated by Receiver Operating Characteristic(ROC).Kaplan-Meier method was used to plot the survival curve to explore the relationship between T cell subsets and EGFR expression level and prognosis of lung adenocarcinoma patients.Results:The level of CD8+ and EGFR expression in pathological tissue of lung adenocarcinoma was significantly higher than that in paracancer tissue,while the level of CD4+ was significantly lower than that in paracancer tissue(P<0.05).The levels of CD4+,CD8+ and EGFR expression were correlated with lymph node metastasis,TNM stage and differentiation degree(P<0.05).ROC curve results showed that the AUC values of CD4+,CD8+ and EGFR were 0.547,0.723 and 0.757,respectively,which had certain diagnostic value for lung adenocarcinoma patients.The survival time of high CD4+ was longer than that of low CD4+,the survival time of high CD8+ was shorter than that of low CD8+,and the survival time of EGFR-positive was shorter than that of negative.Conclusion:The expression of CD8+ and EGFR is high in lung adenocarcinoma patients,while the expression of CD4+ is low,which is closely related to the clinical characteristics and prognosis of patients.
T lymphocyte factorEpidermal growth factor receptorLung adenocarcinomaClinical featuresPrognosis
NETL
NSTL
万方数据
维普
