首页|唾液CA-Ⅵ、MMP-2、CCL28与儿童龋病严重程度关系及预测龋病复发价值

唾液CA-Ⅵ、MMP-2、CCL28与儿童龋病严重程度关系及预测龋病复发价值

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目的:探讨唾液碳酸酐酶Ⅵ(Carbonic anhydrase Ⅵ,CA-Ⅵ)、基质金属蛋白酶-2(Matrix metalloproteinase-2,MMP-2)、CC趋化因子配体 28(CC chemokine ligand 28,CCL28)水平在判断儿童龋病病情及预测龋病复发中的应用效果.方法:选取 2019 年4 月至 2022 年4 月我院收治且均完成 1 y随访的 86 例龋病者为研究对象.根据龋失补指数(decay missing fill index,DMFT)将患者分为低龋组(39 例,DMFT=1～4)和高龋组(47 例,DMFT≥5).根据治疗后 1 y复发情况将患者分为复发(24 例)和未复发(62 例).比较低龋组和高龋组入院时唾液CA-Ⅵ、MMP-2、CCL28 水平及与DMFT的相关性;比较复发、未复发患者唾液CA-Ⅵ、MMP-2、CCL28 水平.分析CA-Ⅵ、MMP-2、CCL28 水平对龋病复发的危险度.分析CA-Ⅵ、MMP-2、CCL28 水平预测龋病复发的价值.结果:入院时高龋组唾液CA-Ⅵ水平低于低龋组,与DMFT呈负相关;高龋组唾液MMP-2、CCL28 水平高于低龋组,与DMFT呈正相关(P＜0.05).入院时、治疗后 1 m时复发者唾液CA-Ⅵ水平均明显低于未复发者,MMP-2、CCL28 水平均明显高于未复发者(P＜0.05).CA-Ⅵ、MMP-2、CCL28 水平联合预测龋病复发AUC为 0.808,最佳敏感度、特异度分别为 91.67%、77.42%.结论:唾液CA-Ⅵ、MMP-2、CCL28 水平的变化对儿童龋病病情判断提供参考依据,对预后评估具有重要意义.
Relationship between salivary CA-Ⅵ,MMP-2,CCL28 and caries severity in children and their value in predicting caries recurrence
Objective:To investigate the effects of salivary carbonic anhydrase Ⅵ(CA-Ⅵ),matrix metalloproteinase-2(MMP-2),and CC chemokine ligand 28(CCL28)levels in determining the caries condition and predicting the recurrence of caries in children.Methods:86 patients with caries who were admitted to our hospital from April 2019 to April 2022 and completed 1-year follow-up were selected as the study objects.According to the caries loss index(DMFT),the patients were divided into low caries group(39 cases,DMFT= 1-4)and high caries group(47 cases,DMFT≥5).The patients were divided into recurrence(24 cases)and non-recurrence(62 cases)according to the recurrence rate 1 year after treatment.The levels of CA-Ⅵ,MMP-2,CCL28 in saliva and their correlation with DMFT were compared between the low caries group and the high caries group.The levels of CA-Ⅵ,MMP-2 and CCL28 in saliva of patients with and without relapse were compared.The risk of recurrence of caries at CA-Ⅵ,MMP-2 and CCL28 levels was analyzed.The values of CA-Ⅵ,MMP-2 and CCL28 levels in predicting caries recurrence were analyzed.Results:Salivary CA-Ⅵ level in the high caries group was lower than that in the low caries group at the time of admission,which was negatively correlated with DMFT;salivary MMP-2 and CCL28 levels in the high caries group were higher than those in the low caries group,which were positively correlated with DMFT(P<0.05).Salivary CA-Ⅵ levels in recurrence group were significantly lower than those in non-recurrence group at the time of admission and at 1 month after treatment;and the levels of MMP-2 and CCL28 in recurrence group were significantly higher than those in non-recurrence group(P<0.05).The AUC for the combined prediction of caries relapse of CA-Ⅵ,MMP-2,and CCL28 levels was 0.808,and the optimal sensitivity and specificity were 91.67%and 77.42%,respectively.Conclusion:The changes of CA-Ⅵ,MMP-2 and CCL28 levels in saliva can provide reference for the diagnosis of caries in children,and have important significance for prognosis assessment.

CariesThe degree of severityRecurrenceCA-ⅥMMP-2CCL28

高静、吴昊、谢静娜

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河南省漯河市郾城区中医院口腔科,河南 漯河 462300

龋病 严重程度 复发 CA-Ⅵ MMP-2 CCL28

2024

四川生理科学杂志
四川省生理科学会

四川生理科学杂志

影响因子：0.575
ISSN：1671-3885
年,卷(期)：2024.46(4)
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