首页|Association between Mental Disorders and Subsequent Medical Conditions
Association between Mental Disorders and Subsequent Medical Conditions
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
万方数据
维普
Background:Persons with mental disorders are at a higher risk than the general population for the subsequent development of certain medical conditions.Methods:We used a population-based cohort from Danish national registries that included data on more than 5.9 million persons born in Denmark from 1900 through 2015 and followed them from 2000 through 2016,for a total of 83.9 million person-years.We assessed 10 broad types of mental disorders and 9 broad categories of medical conditions(which encompassed 31 specific conditions).We used Cox regression models to calculate overall hazard ratios and time-dependent hazard ratios for pairs of mental disorders and medical conditions,after adjustment for age,sex,calendar time,and previous mental disorders.Absolute risks were estimated with the use of competing-risks survival analyses.Results:A total of 698,874 of 5,940,299 persons(11.8％)were identified as having a mental disorder.The median age of the total population was 32.1 years at entry into the cohort and 48.7 years at the time of the last follow-up.Persons with a mental disorder had a higher risk than those without such disorders with respect to 76 of 90 pairs of mental disorders and medical conditions.The median hazard ratio for an association between a mental disorder and a medical condition was 1.37.The lowest hazard ratio was 0.82 for organic mental disorders and the broad category of cancer(95％confidence interval[CI],0.80 to 0.84),and the highest was 3.62 for eating disorders and urogenital conditions(95％CI,3.11 to 4.22).Several specific pairs showed a reduced risk(e.g.,schizophrenia and musculoskeletal conditions).Risks varied according to the time since the diagnosis of a mental disorder.The absolute risk of a medical condition within 15 years after a mental disorder was diagnosed varied from 0.6％for a urogenital condition among persons with a developmental disorder to 54.1％for a circulatory disorder among those with an organic mental disorder.Conclusions:Most mental disorders were associated with an increased risk of a subsequent medical condition;hazard ratios ranged from 0.82 to 3.62 and varied according to the time since the diagnosis of the mental disorder.
Natalie C Momen
展开 >
Danish National Research Foundation and othersCOMO-GMC ClinicalTrials.gov
NETL
NSTL
万方数据
维普
