Effect analysis of NCPAP,nebulization combined with IHIG in the treatment of severe pneumonia
Objective:To investigate the effect of Nasal high flow positive pressure ventilation(NCPAP),aerosol inhalation combined with Human immunoglobulin(IHIG)in the treatment of patients with severe pneumonia.Methods:A total of 82 patients with severe pneumonia admitted to the hospital from February 2021 to February 2023 were divided into control group and observation group by random number table method,with 41 cases in each group.The control group received conventional treatment,and the observation group received NCPAP+ nebulization +IHIG combined treatment on this basis.The therapeutic effects of thetwo groups were analyzed and compared.Lung function was detected by pulmonary function instrument before and 5 days after treatment,and Tumor Necrosis Factor-α(TNF-α)and endothelin-1(ET-1)were detected by enzyme-linked immunotherapy.Results:The effective rate of observation group was higher than that of control group(P<0.05).After intervention,the lung function level of the observation group was significantly better than that of the control group(P<0.05).After intervention,the levels of TNF-α and ET-1 in the observation group were significantly lower than those in the control group(P<0.05).Conclusion:The combination of NCPAP+ nebulize inhalation +IHIG can improve the therapeutic effect,improve lung function,and reduce the expression of TNF-α and ET-1 in severe pneumonia.
Severe pneumoniaNasal high flow positive pressure ventilationAtomizing inhalationHuman immunoglobulin
NETL
NSTL
万方数据
维普
