HPV、TCT检查在子宫颈癌前病变筛查中的价值分析
Value analysis of HPV and TCT in screening of cervical precancerous lesions
南静 1王静2
作者信息
- 1. 灵宝市第二人民医院病理科,河南 灵宝 472500
- 2. 灵宝市第二人民医院妇产科,河南 灵宝 472500
- 折叠
摘要
目的:分析人乳头瘤病毒(Human Papilloma Virus,HPV)、宫颈液基细胞学检查(Thin-Cytologic Test,TCT)在子宫颈病变筛查中的临床价值.方法:选取 2020 年7 月至 2023 年7 月期间在本院进行子宫颈癌前病变筛查的疑似子宫颈癌前病变患者 2614例作为研究对象.所有患者均进行HPV与TCT检查,将病理学的检验结果作为本研究的金标准,比较HPV与TCT这两种检验方法的检查结果,分析HPV、TCT检查分别在子宫颈癌前病变早期筛查中的实际临床价值.结果:2614 例疑似子宫颈癌前病变患者中经病理检查,阳性检出率为 8.22%.HPV检查阳性检出率为 8.11%,与病理学检验结果间的Kappa值为 0.6855;经TCT检查阳性检出率为 2.98%,与病理学检验结果间的Kappa值为 0.4182;联合检查阳性检出率为 8.19%,与病理学检验结果间的Kappa值为0.7383;对子宫颈癌前病变诊断的检查灵敏度、特异度、准确度、阳性预测值和阴性预测值分别如下,HPV 检查为 69.77%、97.62%、95.33%、72.46%、97.30%;TCT检查为30.23%、99.46%、93.46%、83.33%、94.09%;联合检查为 74.88%、97.79%、95.91%、75.23%、97.75%;结论:HPV和TCT检查均适用于在早期子宫颈癌前病变的筛查,且其更加简单快捷,对患者的创伤较小,推荐在临床使用.
Abstract
Objective:To analyze the clinical value of Human Papilloma Virus(HPV)and Thin-Cytologic Test(TCT)in screening cervical lesions.Methods:A total of 2614 patients with suspected cervical prelesions who underwent screening for cervical prelesions in our hospital from July 2020 to July 2023 were selected as the study objects.All patients underwent HPV and TCT examination,and pathological examination results were taken as the gold standard of this study.The results of HPV and TCT examination were compared,and the actual clinical value of HPV and TCT examination in the early screening of cervical precancerous lesions was analyzed.Results:The positive rate of 2614 patients with suspected precancerous lesions of cervical cancer was 8.22%.The positive rate of HPV was 8.11%,and the Kappa value between HPV and pathological test was 0.6855.The positive rate of TCT examination was 2.98%,and the Kappa value between TCT examination and pathological examination was 0.4182.The positive rate of combined examination was 8.19%,and the Kappa value between the combined examination and pathological examination was 0.7383.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value for the diagnosis of cervical precancerous lesions were 69.77%,97.62%,95.33%,72.46%,97.30%for HPV.The results of TCT examination were 30.23%,99.46%,93.46%,83.33%and 94.09%.The joint examination was 74.88%,97.79%,95.91%,75.23%,97.75%;Conclusion:Both HPV and TCT are suitable for the screening of precancerous lesions of cervical cancer in the early stage,and they are simpler and faster,less invasive to patients,and are recommended for clinical use.
关键词
人乳头瘤病毒/宫颈液基细胞学检查/子宫颈癌前病变/早期筛查Key words
Human papillomavirus/Cervical fluid based cytology/Cervical precancerous lesions/Early screening引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据