Correlation analysis of serum IL-10,HIF-1α,β2-MG and renal function impairment in patients with glomerulonephritis
Objective:Serum Interleukin-10(IL-10),Hypoxia inducible factor-lalpha(HIF-1α),β2-microglobin(β2-microglobin)were analyzed.Association of β2-MG combined assay with renal function impairment in patients with glomerulonephritis.Methods:110 patients with glomerulonephritis admitted to our hospital from July 2020 to April 2023 were selected as the study objects.According to the Glomerular filtration rate(GFR)level,the patients were grouped into severe renal injury group(n=42).The moderately impaired group(n=37)and the mildly impaired group(n=31).Serum IL-10,HIF-1α,β2-MG and Serum creatinine(Scr),Blood urea nitrogen(BUN)and Cystatin C(CysC)levels of the three groups were compared at admission,and their correlation was analyzed.Receiver Operating Characteristic Curve(ROC)was used to analyze the diagnostic value of combined detection of all indexes on admission to severe renal function injury.Results:The levels of serum IL-10,HIF-1α,β2-MG,sCr,BUN and Cys-C at admission were compared:severely impaired group>moderately impaired group>mildly impaired group(P<0.05);Serum IL-10,HIF-1α and β2-MG were positively correlated with serum sCr,BUN and Cys-C in patients with glomerulonephritis(P<0.05).The Area Under Curve(AUC)of serum IL-10,HIF-1α,and β2-MG levels in patients with combined diagnosis of severely impaired renal function at admission was 0.906.Conclusion:Serum IL-10,HIF-1α,β2-MG levels are closely related to the degree of renal function impairment in patients with glomerulonephritis,and the combined detection of their levels is of great significance for clinical assessment of renal function impairment.
NETL
NSTL
万方数据
维普
