Research progress on the relationship between adrenergic receptors and Alzheimer's disease
Alzheimer's disease(AD)is a neurodegenerative disease that often occurs in people aged above 65,seriously affecting their quality of life.The main pathological feature of AD is the brain β-Amyloid protein(β amloid protein,A β)deposition and excessive phosphorylation of Tau protein.At present,clinical treatment drugs can only alleviate their clinical symptoms but cannot effectively delay or reverse the progression of the disease.Therefore,new therapeutic targets and drugs are urgently need to be addressed.Previous data show that adrenergic receptor(AR)as α2A-AR and β-AR participate in the deposition of A β and Tau phosphorylation process,which may be one of the effective targets for treating AD.This article reviews the role of AR in the occurrence and development of AD,aiming to provide assistance in discovering new therapeutic targets and drugs for AD.
NETL
NSTL
万方数据
维普
