Systematic evaluation of efficacy and safety of liraglutide in the treatment of NAFLD
Objective:To assess the efficacy and safety of liraglutide for treatment of NAFLD.Methods:Relevant literature in Chinese and foreign language literature databases were searched and screened for meta-analysis.Results:A total of 15 studies including 924 patients were included.Mata analysis showed that there was no significant difference in NAFLD resolution rate between liraglutide and control group.Compared to control group,treatment with liraglutide was significantly associated with decrease in liver fat content,liver fibrosis scores and serum ALT.Serum AST and γ-GGT were not significantly improved in liraglutide group when compared with the control group.Furthermore,there was no significant correlation of occurrence rate of adverse events(nausea,vomiting and diarrhea)with liraglutide.Conclusions:Liraglutide treatment can reduce liver fat content,improve liver fibrosis in NAFLD patients,and the gastrointestinal adverse effects of liraglutide are well tolerated in patients.
NETL
NSTL
万方数据
维普
