Comparison of the effects of dezocine and sufentanil on analgesia,agitation,and stress response after pediatric laparoscopic surgery
Objective:To compare the effects of dezocine and sufentanil on analgesia,agitation,and stress response after pediatric laparoscopic surgery.Methods:A total of 62 children who were admitted to our hospital from June 2022 to December 2023 and planned to undergo laparoscopic surgery were selected.They were randomly divided into two groups using a random number table method:the dexamethasone group and the sufentanil group(n=31).dezosin 0.1 mg·kg-1 or sufentanil 0.2 μg·kg-1 were intravenously injected 15 minutes before surgery,respectively.The degree of pain and the occurrence of restlessness during the recovery period between two groups of pediatric patients at different time points after surgery were compared.Before and after surgery,ELISA was used to detect the levels of epinephrine(E)and glucagon(GCG).The occurrence of adverse reactions 30 minutes after extubation and 24 hours after surgery were recorded,and the satisfaction of the families of the two groups of pediatric patients with anesthesia was calculated.Results:The face,legs,activity,cry,consolability behavioral tool(FLACC)scores of the sufentanil group were lower than those of the dezocine group at 4 hours and 8 hours after surgery(P<0.05).After surgery,serum E and GCG levels in the sufentanil group were lower than those in the dezocine group(P<0.05).The total incidence of adverse reactions in the dezocine group was lower than that in the sufentanil group(P<0.05).Conclusion:Both dezocine and sufentanil are safe for pediatric laparoscopic surgery,and sufentanil can achieve a better postoperative analgesic effect than dexamethasone.It has less influence on postoperative stress response,but a higher incidence of adverse reactions.
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