Changes of serum Fbg,IgE and FeNO,and their relationship with disease severity and lung function in patients with stable COPD
Objective:To explore the changes of serum fibrinogen(Fbg),immunoglobulin E(IgE)and fractional exhaled nitric oxide(FENO)in patients with stable chronic obstructive pulmonary disease(CDPD),and to analyze their relationship with disease severity and lung function.Methods:A total of 60 patients with stable COPD(23 mild cases,22 moderate cases,15 severe cases)and 60 healthy controls in the hospital were enrolled as COPD group and control group between August 2020 and November 2023,respectively.The lung function indexes[forced expiratory volume in one second as a percentage of predicted value(FEV1%),peak expiratory flow(PEF),maximum mid-expiratory flow(MMF)]in the two groups were detected.The differences in levels of serum Fbg,IgE and FeNO between the two groups were compared,and the relationship between the three indexes and disease severity was analyzed by Spearman correlation analysis.The correlation between lung function indexes and serum Fbg,IgE,FeNO was analyzed by Pearson correlation analysis.Results:FEV1%,MMF and PEF in COPD group were lower than those in control group(P<0.05),while levels of serum Fbg,IgE and FeNO were higher than those in control group(P<0.05).The levels of serum Fbg,IgE and FeNO were gradually decreased in severe group,moderate group and mild group(P<0.05).The results of Spearman correlation analysis showed that levels of Fbg,IgE and FeNO were positively correlated with disease severity(P<0.05).The results of Pearson correlation analysis showed that Fbg,IgE and FeNO were negatively correlated with FEV1%,MMF and PEF(P<0.05).Conclusion:The levels of serum Fbg,IgE and FeNO are increased in patients with stable COPD,which all can reflect disease severity and lung function to a certain extent.
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