Clinical effect analysis of two insulin administration methods in the treatment of diabetic ketoacidosis complicated with hyperosmolar coma
Objective:Clinical effect analysis of two insulin administration methods on the treatment of diabetic ketoacidosis(DKA)complicated with hyperosmolar nonketotic diabetic coma(HNDC).Methods:84 cases of diabetic DKA patients with HNDC admitted to the Affiliated Hospital of Xinyang Vocational and Technical College were randomly divided into two groups(n=42),both groups were treated with insulin.The control group was given subcutaneous injection,while the observation group was given continuous pumping.Before treatment and 1 day after treatment,before and after three meals and before bedtime,venous blood was extracted from patients,and blood glucose content was measured by blood biochemical testing instrument.Results:After treatment,compared with before treatment,the blood glucose of three meals and the average blood glucose before bedtime of the two groups were significantly decreased(P<0.05),especially in the control group(P<0.05);the time of blood glucose reaching the standard in the observation group was shorter than that in the control group(P<0.05);the time of urine ketone body turning negative in the observation group was shorter than that in the control group,and the dosage of insulin was less than that in the control group;(P<0.05);during intensive treatment,the incidence of hypoglycemia in the observation group was lower than that in the control group(P<0.05).Conclusion:Compared with subcutaneous injection,continuous administration of insulin pump can more stably control blood glucose,promote rapid blood glucose target achievement and rapid negative conversion of blood and urine ketones.
DiabetesInsulinInsulin pumpKetoacetic acidosishypertonic coma
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