Effect of Kangfu Xiaoyan Suppository combined with oral gynecological Qianjin Capsules on the vaginal microenvironment and inflammatory cytokine levels in patients with chronic pelvic inflammatory disease
Objective:To explore and analyze the effects of Kangfu Xiaoyan Suppository combined with oral gynecological Qianjin Capsules on the vaginal microenvironment and inflammatory cytokine levels in patients with chronic pelvic inflammatory disease.Methods:Sixtyfour patients with chronic pelvic inflammatory disease who visited our hospital from January 2020 to November 2023 were randomly divided into an oral medication group(treated with gynecological Qianjin capsules)and an anti-inflammatory suppository group(treated with Kangfu anti-inflammatory suppository in addition to the oral medication group).There were 32 patients in each group,and both groups were treated continuously for 2 weeks.The clinical efficacy,changes in vaginal microenvironment before and after treatment,changes in serum inflammatory factor levels,and incidence of adverse reactions were compared between the two groups.Results:The effective rates of the anti-inflammatory suppository group and the oral medication group after treatment were 93.75%and 75.00%,respectively.Compared with the oral medication group,the anti-inflammatory suppository group was significantly higher,and the difference was statistically significant(P<0.05);The pH value of the vaginal microenvironment in the anti-inflammatory suppository group was lower than that in the oral medication group,and the difference was statistically significant(P<0.05);After 2 weeks of treatment,the serum inflammatory factor levels in the anti-inflammatory suppository group decreased compared to the oral medication group,and the difference was statistically significant(P<0.05);The incidence of adverse reactions in the anti-inflammatory suppository group and the oral medication group were 15.62%and 21.88%,respectively,and there was no statistically significant difference between the two groups(P>0.05).Conclusion:Kangfu Xiaoyan Suppository combined with oral gynecological Qianjin Capsule has good clinical efficacy in the treatment of chronic pelvic inflammatory disease,which can significantly improve the vaginal microenvironment of patients and reduce the content of inflammatory cytokines.
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