Effects of transcranial direct current stimulation combined with sertraline on cognitive function,neurotransmitter levels and sleep status in depressed patients
Objective:To investigate the efficacy of Transcranial direct current stimulation(tDCS)combined with sertraline in the treatment of patients with Major depressive disorder(MDD).Methods:84 MDD patients admitted from January 2020 to June 2023 were included in the study,and were randomly divided into drug group(single number)and combined tDCS group(even number)with 42 cases each,the drug group was treated with sertraline hydrochloride tablets and pseudo-stimulation,and the combined tDCS group was treated with Sertraline hydrochloride tablets and tDCS.Comparing the treatment effect between the two groups,The degree of depression before and after treatment[Cognition distortions questiosaire(CDQ),Hamilton depression scale(HAMD-17),cognitive function[Cancellation Test(NCT),Wisconsin card sorting test(WCST),neurotransmitter levels[gamma-Aminobutyric acid,GABA),Norepinephrine(NE),5-hydroxytryptamine(5-HT)and dopamine(DA),and sleep status[Athens insomnia scale,AIS),Pittsburgh sleep quality index(PSQI)].Results:The effective rate of combined tDCS group(88.10%)was significantly higher than that of drug group(69.05%)(P<0.05).After treatment,the CDQ scores,HAMD-17 scores,AIS and PSQI scores in combined tDCS group were lower than those in drug group(P<0.05),and the correct number of NCT,net score,total WCST responses,correct number of responses and completed classification numbers were higher than those in drug group(P<0.05).The number of NCT errors,missed marks and persistent errors of WCST were lower than those of drug group(P<0.05).The levels of GABA,NE,5-HT and DA in combined tDCS group were significantly higher than those in drug group(P<0.05).Conclusion:tDCS combined with sertraline can effectively alleviate depressive symptoms in MDD patients,improve cognitive function,neurotransmitter levels,and improve sleep status.
DepressionTranscranial direct current stimulationSertralineCognitive functionNeurotransmitter levelsSleep status
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