布地奈德治疗联合呼吸训练对慢性阻塞性肺疾病的治疗效果研究
Effect of budesonide therapy combined with breathing training on chronic obstructive pulmonary disease
李晓云 1赵香玲 2张行1
作者信息
- 1. 许昌市中心医院门诊部,河南 许昌 461002
- 2. 许昌市中心医院急诊综合病房,河南 许昌 461002
- 折叠
摘要
目的:探讨呼吸训练联合布地奈德对慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)患者肺功能指标与炎症指标的影响.方法:选取 2021 年 3 月至 2023 年 3 月本院收治的 86 例COPD患者,随机分为对照组和研究组(n=43),分别予以常规治疗以及采用呼吸训练仪进行呼吸训练联合布地奈德(吸入用布地奈德混悬液 2 mg+0.9%氯化钠溶液 4 mL雾化吸入)治疗.比较两组肺功能的肺活量(Forced vital capacity,FVC)、第 1 秒用力呼气容积(Forced expiratory volume in 1 second,FEV1)、FEV1/FVC、最大呼气中期流速(Maximal mid-expiratory flow,MMEF)和炎症指标的C-反应蛋白(C-reactive protein,CRP)、白细胞计数(White blood cell,WBC)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白介素-6(Interleukin-6,IL-6)以及生活质量.结果:治疗 1 w后,研究组的FVC、FEV1、FEV1/FVC、MMEF及炎症指标CRP、WBC、TNF-α、IL-6 改善情况显著优于对照组;且研究组生活质量评分均显著高于对照组(P＜0.05).结论:对COPD患者采用呼吸训练与布地奈德联合治疗,能够提高患者肺功能,减轻炎症反应,提高生活质量.
Abstract
Objective:To investigate the effects of respiratory training combined with budesonide on pulmonary function and inflammation in chronic obstructive pulmonary disease(COPD)patients.Methods:Eighty-six patients with chronic obstructive pulmonary disease(COPD)admitted to our hospital from March 2021 to March 2023 were randomly divided into a control group and a study group(n=43).All the patients were treated with routine therapy or the respiratory training apparatus combined with Budesonide(2 mg inhalation of budesonide suspension plus 4 mL of 0.9%sodium chloride solution nebulized inhalation),respectively.Forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1),FEV1/FVC,maximal mid-expiratory flow(MMEF),and c-reactive protein(CRP),white blood cell count(WBC),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and quality of life were compared between the two groups.Results:After one week of treatment,the improvement of FVC,FEV1,FEV1/FVC,MMEF,CRP,WBC,TNF-α,and IL-6 in the study group were significantly better than those in the control group,and the scores of quality of life in the study group were significantly higher than those in the control group(P<0.05).Conclusion:The combination of respiratory training and budesonide in COPD patients can improve lung function,reduce inflammation,and improve quality of life.
关键词
呼吸训练仪/布地奈德/慢性阻塞性肺疾病/肺功能/炎症指标Key words
Respiratory training apparatus/Budesonide/Chronic obstructive pulmonary disease/Lung function/Inflammatory index引用本文复制引用
出版年
2024
NETL
NSTL
万方数据