Effect of budesonide therapy combined with breathing training on chronic obstructive pulmonary disease
Objective:To investigate the effects of respiratory training combined with budesonide on pulmonary function and inflammation in chronic obstructive pulmonary disease(COPD)patients.Methods:Eighty-six patients with chronic obstructive pulmonary disease(COPD)admitted to our hospital from March 2021 to March 2023 were randomly divided into a control group and a study group(n=43).All the patients were treated with routine therapy or the respiratory training apparatus combined with Budesonide(2 mg inhalation of budesonide suspension plus 4 mL of 0.9%sodium chloride solution nebulized inhalation),respectively.Forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1),FEV1/FVC,maximal mid-expiratory flow(MMEF),and c-reactive protein(CRP),white blood cell count(WBC),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and quality of life were compared between the two groups.Results:After one week of treatment,the improvement of FVC,FEV1,FEV1/FVC,MMEF,CRP,WBC,TNF-α,and IL-6 in the study group were significantly better than those in the control group,and the scores of quality of life in the study group were significantly higher than those in the control group(P<0.05).Conclusion:The combination of respiratory training and budesonide in COPD patients can improve lung function,reduce inflammation,and improve quality of life.
Respiratory training apparatusBudesonideChronic obstructive pulmonary diseaseLung functionInflammatory index
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