丁苯肽联合阿司匹林+氯吡格雷治疗ACI的临床疗效观察
Clinical efficacy of butadiphenylpeptide combined with aspirin and clopidogrel in the treatment of ACI
戈念念 1闫向敏 1闫如冰 1刘建军1
作者信息
- 1. 商丘市第四人民医院神经内科,河南 商丘 476000
- 折叠
摘要
目的:分析丁苯肽联合阿司匹林+氯吡格雷治疗急性脑梗死(ACI)的临床疗效.方法:回顾性收集本院 2022年 12 月-2023 年6 月收治的 98例ACI患者的临床资料.根据不同的治疗方式将患者分为对照组(阿司匹林+氯吡格雷,48 例)和观察组(丁苯肽联合阿司匹林+氯吡格雷,50 例).分析对比两组的临床疗效、神经功能及肢体运动、凝血功能以及不良反应发生率.结果:观察组的临床疗效显著高于对照组(P＜0.05).治疗后,两组的NIHSS评分显著下降、FMA评分显著升高,且观察组的NIHSS评分显著低于对照组,FMA评分显著高于对照组(P＜0.05).治疗后,两组的FIB水平均呈下降趋势、APTT、PT水平均呈上升趋势,且观察组的FIB水平下降幅度显著大于对照组,APTT、PT水平上升幅度显著大于对照组(P＜0.05).两组的不良反应发生率无显著差异(P＞0.05).结论:丁苯肽联合阿司匹林+氯吡格雷治疗可提高ACI患者临床疗效,促进患者神经功能及肢体运动功能的恢复,改善凝血功能,且具有较高的安全性.
Abstract
Objective:To analyze the clinical efficacy of butadiphenylpeptide combined with aspirin and clopidogrel in the treatment of acute cerebral infarction(ACI).Methods:The clinical data of 98 patients with ACI admitted to our hospital from December 2022 to June 2023 were retrospectively collected.According to different treatment methods,the patients were divided into control group(aspirin+clopidogrel,48 cases)and observation group(butadiphenylpeptide combined with aspirin+clopidogrel,50 cases).The clinical efficacy,neurological function and limb movement,coagulation function and incidence of adverse reactions were analyzed and compared between the two groups.Results:The clinical effect of observation group was significantly higher than that of control group(P<0.05).After treatment,NIHSS score was significantly decreased and FMA score was significantly increased in both groups,and NIHSS score in observation group was significantly lower than that in control group,FMA score was significantly higher than that in control group(P<0.05).After treatment,the FIB level of both groups showed a downward trend,and the APTT and PT levels showed an upward trend,and the decrease of FIB level in the observation group was significantly greater than that in the control group,and the increase of APTT and PT levels was significantly greater than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The treatment of butadiphenylpeptide combined with aspirin and clopidogrel can improve the clinical efficacy of ACI patients,promote the recovery of nerve function and limb motor function,improve coagulation function,and has a high safety.
关键词
丁苯酞/阿司匹林/氯吡格雷/ACI/临床疗效Key words
Butylphthalein/Aspirin/Clopidogrel/ACI/Clinical effect引用本文复制引用
出版年
2024
NETL
NSTL
万方数据