Effect of glutathione tablet combined with adenosylmethionine for injection in the treatment of intrahepatic cholestasis of pregnancy
Objective:To investigate the clinical effect of Glutathione(Glutathione,GSH)tablets combined with Adenosine methionine(AME)in the treatment of intrahepatic cholestasis of pregnancy(ICP).Methods:124 ICP patients admitted to our hospital from February 2020 to February 2022 were selected as the study objects.The patients were randomly divided into control group and study group,62 cases in each group.The control group was treated with AME for injection;patients in the study group were administered with GSH Tablets on the basis of the control group.Before treatment and at the end of 12 days of treatment,the levels of liver function indexes were measured.The disappearance time of symptoms and the occurrence of adverse reactions in the two groups were observed and counted,and the adverse pregnancy outcomes of the two groups were statistically analyzed.Results:After 12 days of treatment,the liver function indexes in the study group were significantly lower than those in the control group(P<0.05).The disappearance time of skin pruritus and jaundice in the study group was significantly shorter than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups.The vaginal delivery rate of the study group was significantly higher than that of the control group,the cesarean section rate and the incidence of fetal distress were significantly lower than that of the control group(P<0.05).There was no significant difference in the incidence of abortion between the two groups.Conclusion:GSH tablets combined with AME for injection in the treatment of ICP can promote the disappearance of symptoms,improve liver function,reduce adverse reactions and adverse pregnancy outcomes.
Intrahepatic cholestasis of pregnancyGlutathione tabletsAdenosylmethionineLiver function
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