Effect of magnesium sulfate combined with progesterone therapy on sex hormones and pregnancy outcomes in patients with threatened preterm labor
Objective:To explore the effect of magnesium sulfate combined with progesterone therapy on sex hormones and pregnancy outcomes in patients with threatened preterm labor.Methods:A total of 78 patients with threatened preterm labor admitted to our hospital from March 2021 to March 2023 were selected as the research objects.According to the lottery selection,the research objects were randomly divided into control group and study group,with 39 cases in each group.The control group was treated with magnesium sulfate diluted in glucose injection,and the study group was treated with magnesium sulfate combined with progesterone.The sex hormone levels,pregnancy outcomes and adverse reactions of the two groups were analyzed and compared.Results:After treatment,the levels of Progesterone(P),Blood Serum Estradiol(E2)and Human Chorionic Gonadotrophin(HCG)in the study group were significantly higher than those in the control group(P<0.05).The full-term delivery rate of the study group was significantly higher than that of the control group(P<0.05),and the birth asphyxia rate of the study group was significantly lower than that of the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the control group and the study group(P>0.05).Conclusion:Magnesium sulfate combined with progesterone therapy can effectively improve the sex hormone levels and adverse pregnancy outcomes in patients with threatened preterm labor.In addition,it can effectively improve birth asphyxia and increase the full-term delivery rate,which effect is remarkable with no obvious side effects and well safety.
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