Effect of pemetrexed combined with cisplatin in postoperative chemotherapy of lung adenocarcinoma
Objective To investigate the effect of Pemetrexed(PEM)combined with cisplatin in postoperative chemotherapy of lung adenocarcinoma.Methods:81 patients with lung adenocarcinoma were selected as the study objects.Patients were randomly divided into control group(n=40)and observation group(n=41).The control group was given intravenous docetaxel and cisplatin,and the observation group was given intravenous PEM and cisplatin.The clinical efficacy,Cytokeratin-19-fragment(CYFRA21-1),Carcinoembryonic antigen(CEA),Neuron-specific enolase(NSE)levels,toxic and side effects,and near-term survival of the two groups were analyzed and compared.Results:After treatment,there was no significant difference in clinical remission rate between the two groups.The clinical control rate of observation group was significantly higher than that of control group(P<0.05).At the end of treatment,serum CYFRA21-1,CEA and NSE levels in both groups were significantly decreased,and the observation group was significantly lower than the control group(P<0.05).The incidence of toxic and side effects in the observation group was significantly lower than that in the control group(P<0.05).There was no significant difference in short-term survival between the two groups.Conclusion:Chemotherapy with PEM combined with cisplatin can improve the clinical control rate,reduce the level of tumor-related indicators,and do not increase the side effects of lung adenocarcinoma.
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