Clinical effects of Qingjin Huatan decoction with budesonide and terbutaline sulfate atomization in the treatment of patients with AECOPD
Objective:To investigate the clinical efficacy of Qingjin Huatan decoction with budesonide and terbutaline sulfate atomization in the treatment of acute exacerbation chronic obstructive pulmonary disease(AECOPD).Methods:All 114 patients with AECOPD admitted to Yucheng County People's Hospital from January 2022 to June 2023 were collected and divided into conventional western medicine group and traditional Chinese medicine(TCM)auxiliary group by randomized controlled experiment,57 cases in each group.The conventional western medicine group was treated with symptomatic supportive treatment,budesonide and terbutaline sulfate atomization,the TCM auxiliary group was treated with Qingjin Huatan decoction on the basis of conventional western medicine group.After 2 weeks of treatment,the clinical efficacy was compared between the two groups;before and after 2 weeks of treatment,blood gas analyzer was used to detect blood gas indexes oxygen partial pressure(PaO2),oxygen saturation(SaO2),partial pressure of carbon dioxide(PaCO2);lung function tester was used to detect pulmonary function indexes forced vital capacity(FVC),forced expiratory volume in one second/forced vital capacity(FEV1/FVC),peak expiratory flow(PEF),maximal voluntary ventilation(MVV);Enzyme-linked immunosorbent assay was used to detect inflammatory factors interleukin(IL)-6,IL-17,tumor necrosis factor-α(TNF-α).Results:The total effective rate of TCM auxiliary group was higher than that of conventional western medicine group(P<0.05).After 2 weeks of treatment,the levels of PaCO2,serum TNF-α,IL-6 and IL-17 in TCM auxiliary group were lower than those in conventional western medicine group,and SaO2,PaO2,FVC,FEV1/FVC,PEF and MVV were higher than those in conventional western medicine group(P<0.05).Conclusion:Qingjin Huatan decoction with conventional western medicine can effectively improve blood gas indexes,enhance lung function,reduce inflammatory reaction,and further improve clinical efficacy.
Acute exacerbation of chronic obstructive pulmonary diseaseQingjin Huatan decoctionTerbutaline sulfateBudesonide
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