Effects of gastrodin capsule combined with carbamazepine on clinical efficacy,blinking reflex,pain degree and sleep quality of PTN patients
Objective:To investigate the effects of gastrodin capsule combined with carbamazepine on clinical efficacy,blinking reflex,pain degree and sleep quality in patients with primary trigeminal neuralgia(PTN).Methods:All 78 patients with PTN admitted to Yucheng County People's Hospital from June 2021 to June 2023 were collected as research objects.According to the principle of randomized control,all patients were divided into traditional Chinese medicine(TCM)combination group and western medicine group,39 cases in each group.The western medicine group was treated with carbamazepine,and the TCM combination group was treated with gastrodin capsule on the basis of the western medicine group.After 1 month of treatment,the curative effect,blink reflex(R1,R2,and R2'incubation period),serum indexes nerve growth factor(NGF),tumor necrosis factorα(TNF-α),pain level,sleep quality,occurrence of adverse reactions were compared between the two groups.Results:After treatment,the total effective rate of TCM combination group(94.87%)was significantly higher than that of western medicine group(79.49%)(P<0.05),blinking reflex R1,R2 and R2'latency in TCM combination group were shorter than those in western medicine group,and serum levels of NGF and TNF-α,visual analog scale(VAS)score and Pittsburgh sleep quality index(PSQI)score in TCM combination group were lower than those in western medicine group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Gastrodin capsule combined with carbamazepine in the treatment of PTN patients can effectively improve clinical efficacy,reduce blinking reflex and inflammatory response,reduce pain,improve sleep quality,and have high drug safety.
Gastrodin capsuleCarbamazepinePrimary trigeminal neuralgiaDegree of painBlinking reflex
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NSTL
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