Effects of Qishenyiqi dropping pills combined with isosorbide mononitrate and clopidogrel on clinical efficacy,heart function,coronary blood flow and platelet function in patients with unstable angina pectoris of coronary heart disease
Objective:To investigate the clinical efficacy of Qishenyiqi dropping pills combined with isosorbide mononitrate and clopidogrel in the treatment of patients with unstable angina pectoris(UA)of coronary heart disease.Methods:All 100 patients with UA admitted to Xiuwu Hospital of Traditional Chinese Medicine from January 2022 to June 2023 were collected and randomly divided into conventional western medicine group and traditional Chinese medicine(TCM)combined group.The conventional western medicine group was treated with isosorbide mononitrate and clopidogrel orally,and the TCM combined group was treated with Qishenyiqi dropping pills orally on the basis of conventional Western medicine.After 4 weeks of treatment,the clinical curative effect,heart function indexes left ventricular end-diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),left isovolumic relaxation time(IVRT),left ventricular ejection fraction(LVEF),coronary blood flow parameters peak systolic velocity(PSV),peak diastolic velocity(PDV),platelet function indicators platelet P-selectin(CD62P),maximum platelet aggregation rate(MPAR),platelet glycoprotein(GP)Ⅱb/Ⅲa,lysosomal membrane protein(CD63),cardiac enzyme indexes cardiac troponinⅠ(cTnⅠ),creatine kinase isoenzyme(CK-MB),N-terminal pro-brain natriuretic peptide(NT-proBNP)and adverse reactions were compared between two groups.Results:After treatment,the total effective rate of TCM combined group was obviously higher than that of conventional western medicine group(P<0.05).LVEF in TCM combined group was obviously higher than that in conventional western medicine group,LVESD,LVEDD and IVRT were obviously lower than those in conventional Western medicine group(P<0.05).PSV and PDV in TCM combined group were obviously higher than those in conventional western medicine group,CD62P,MPAR,GPⅡb/Ⅲa,CD63,NT-proBNP,cTnⅠ,CK-MB were obviously lower than those in conventional Western medicine group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Qishenyiqi dropping pills combined with isosorbide mononitrate and clopidogrel can improve the clinical efficacy of UA patients with coronary heart disease,improve cardiac function,coronary blood flow and platelet function,and help patients recover from the disease.
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