Correlation of serum GSP,HbA1c,IGF-1 levels with pregnancy outcomes in patients with gestational diabetes mellitus and the value of combined detection for early prediction of adverse pregnancy outcomes
Objective:To investigate the correlation of serum glycosylated serum protein(GSP),glycated hemoglobin A1c(HbA1c),insulin-like growth factor-1(IGF-1)with pregnancy outcomes in patients with gestational diabetes mellitus(GDM),and the predictive value of combined detection for adverse pregnancy outcomes.Methods:A total of 127 GDM patients diagnosed at 24-28 weeks of gestation admitted to Xinzheng Huaxin People's Hospital from May 2021 to May 2023 were selected as the GDM group,and 127 healthy pregnant women examined at 24-28 weeks of gestation during the same period were selected as the normal control group.Serum of GSP,HbA1c and IGF-1 levels were compared between GDM group and normal control group.According to pregnancy outcomes,127 GDM patients were divided into poor pregnancy outcomes and good pregnancy outcomes.Serum GSP,HbA1c and IGF-1 levels were compared between GDM patients with poor pregnancy outcomes and good pregnancy outcomes.The correlation of serum GSP,HbA1c,IGF-1 levels with adverse pregnancy outcomes in GDM patients was analyzed.The combined detection value of serum GSP,HbA1c and IGF-1 levels in the early prediction of adverse pregnancy outcomes in GDM patients was analyzed.Results:The serum levels of GSP and HbA1c in GDM group were higher than those in normal control group,and the serum level of IGF-1was lower than that in normal control group(P<0.05).The serum levels of GSP and HbA1c in GDM patients with adverse pregnancy outcome were higher than those in good pregnancy outcome,and the serum level of IGF-1 was lower than that in good pregnancy outcome(P<0.05).Serum levels of GSP and HbA1cwere positively correlated with adverse pregnancy outcomes,while serum level of IGF-1 was negatively correlated with adverse pregnancy outcomes(P<0.05).The area under curve(AUC)combined detection of serum levels of GSP,HbA1c and IGF-1 predicting adverse pregnancy outcomes of GDM patients was 0.872,which was higher than the above indicators alone 0.738,0.776 and 0.723(P<0.05).Conclusion:The serum levels of GSP,HbA1c and IGF-1 are closely related to the occurrence of adverse pregnancy outcomes in GDM patients,and their combined detection can be used as serological indexes to predict adverse pregnancy outcomes in GDM patients in early clinical stage.
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