Effect of tripterygium glycosides combined with methimazole and hormone shock on the efficacy,thyroid function,and immune function of patients with hyperthyroidism infiltrating exophthalmos
Objective:To investigate the effects of tripterygium glycosides combined with methimazole and hormone shock on the efficacy,thyroid function,and immune function of patients with hyperthyroidism infiltrating exophthalmos.Methods:A total of 86 patients with hyperthyroidism infiltrating exophthalmos admitted to Jinshui District General Hospital of Zhengzhou City from January 2022 to June 2023 were selected and divided into the western medicine group and the Chinese medicine combined group by random number table method(n=43).The western medicine group was treated with methimazole(Orally,10 mg·d-1,3 times·d-1)and hormone shock therapy(methylprednisolone sodium succinate,intravenous infusion,1000 mg·time-1,once every other day,continuous impact treatment for 3 times was 1 course,1 month was 1 course),and the Chinese medicine combined group was treated with tripterygium glycosides(Orally,20 mg·d-1,3 times·d-1)based on the western medicine group.After three months of treatment,the clinical efficacy and symptom improvement were compared between the two groups,the radioimmunoassay was used to detect the serum levels of thyroid receptor antibody(TRAb),thyroglobulin antibody(TGAb),thyroid peroxidase antibody(TPOAb),interleukin-6(IL-6)and transforming growth factor(TGF-β1),enzyme-linked immunoassay was used to detect the serum levels of parathyroid hormone(PTH),insulin-like growth factor-1(IGF-1),insulin-like growth factor binding protein-3(IGFBP-3),Attune NxT flow cytometry was used to detect the serum levels of cluster of differentiation(CD)3+,CD4+,CD4+/CD8+.Results:After treatment,the total clinical effective rate of the Chinese medicine combined group was 88.37%,which was higher than that of the western medicine group(69.77%,P<0.05).Compared with pretreatment,the ocular protrusion,exophthalmosis,ocular pressure,and eyelid cleft height in the two groups after treatment were significantly lower,the body mass was significantly higher,and the Chinese medicine combined group was more significant(P<0.05).Also,after treatment the serum levels of PTH,TGAb,TPOAb,TRAb,TGF-β1,IGF-1,IL-6,and IGFBP-3 in the two groups were significantly decreased(P<0.05),the serum levels of CD3+,CD4+,and CD4+/CD8+were significantly increased(P<0.05),especially in the Chinese medicine combined group(P<0.05).
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