Effect of intracavitary embolization with spring coil on nerve function and vascular endothelial function in patients with high-grade subarachnoid aneurysm
Objective:To investigate the effect of endovascular embolization on nerve function and vascular endothelial function in patients with high-grade subarachnoid aneurysm.Methods:A total of 81 patients with high-grade subarachnoid aneurysm hemorrhage from April 2020 to April 2023 were selected.Patients were divided into the control group(n=40)and the observation group(n=41),respectively,and the control group.were given intracavitary embolization while the observation group was given intracavitary embolization Vascular endothelial function,nerve function,aneurysm occlusion and postoperative complications were compared between the two groups.Results:3 months after operation,the serum levels of vascular endothelial growth factor,endothelin-1 and nitric oxide synthase were decreased in both groups,and the observation group was lower than the control group(P<0.05).Three months after surgery,the outcome of the National Institutes of Health Stroke Scale and Modified Rankin Scale(mRS)in the observation group was better than that in the control group(P<0.05).The Raymond grade of aneurysm occlusion in the observation group was better than that in the control group immediately and 3 months after surgery(P<0.05).The total complication rate of observation group was lower than that of control group(P<0.05).Conclusion:Endovascular embolization with spring coil can improve nerve function and vascular endothelial function in patients with high-grade subarachnoid aneurysm hemorrhage,promote aneurysm occlusion,reduce complications and improve clinical prognosis.
Embolization with spring coilHigh grade aneurysmSubarachnoid hemorrhageVascular endothelial function
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