Prognostic significance of tumor growth pattern and tumor budding in patients with gastric cancer
Objective:To evaluate the prognostic significance of tumor growth pattern(TGP)and tumor budding(TB)in patients with gastric cancer.Methods:Eighty-two patients who underwent radical surgery for gastric cancer in our hospital from June 2021 to January 2023 were selected,and pathological tissues were collected for the evaluation of TGP and TB,then the patients were classified into expansive/invasive groups and low/high TB groups.Overall survival(OS)and disease-free survival(DFS)were analyzed by the Kaplan-Meier method,and Cox proportional hazards model regression analysis was used to identify prognostic factors of gastric cancer.Results:Of the 82 patients with gastric cancer,4 had recurrence/metastasis and 22 died.In terms of TGP,29 patients classified as expansive growth pattern and 23 patients as intermediate growth pattern were set as expansive group,and 30 patients classified as invasive growth pattern were included in invasive group.In terms of TB,37 cases of low budding(TB1)and 30 cases of intermediate budding(TB2)were set as low TB group,and 15 cases of high budding(TB3)were classified into high TB group.Statistical difference was reported between the expansive group and invasive group in terms of the degree of differentiation,TNM staging,T staging,N staging,carcinoembryonic antigen(CEA)values,OS,and DFS(P<0.05).The low TB group and high TB group demonstrated statistical differences in the degree of differentiation,TNM stage,N stage,OS,and DFS(P<0.05).Multivariate Cox proportional hazards analysis denoted that TGP and TB were independent influencing factors for postoperative OS in gastric cancer patients,while TGP was an independent influencing factor for DFS(P＜0.05).Conclusion:Both TGP and TB are independent factors affecting the prognosis of gastric cancer patients,and both are of certain predictive value for the prognosis of gastric cancer patients.
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