Clinical observation of omeprazole combined with octreotide in the treatment of upper gastrointestinal bleeding
Objective:To investigate the clinical efficacy and safety of omeprazole combined with octreotide in the treatment of upper gastrointestinal bleeding(UGIB).Methods:80 UGIB patients admitted to our hospital from July 2018 to July 2022 were selected as the study objects.The patients were divided into observation group and control group with 40 cases in each group by random number table method.The control group received intravenous injection and infusion of omeprazole for treatment,while the observation group received intravenous injection and pump assisted treatment of octreotide on the basis of the control group.Both groups were treated for 7 days.Clinical related indexes,coagulation indexes[platelet count(PLT),fibrinogen(FIB)],renal function indexes[blood urea nitrogen(BUN),serum creatinine(Scr)]and adverse reactions of the two groups were analyzed and compared.The patients were followed up for 1 year after treatment,and the recurrence rates of the two groups were compared.Results:The observation group had significantly shorter successful hemostasis time,bowel sound recovery time,and hospital stay compared to the control group(P<0.05).After treatment,the levels of PLT and FIB in both groups increased,and the PLT and FIB levels in the observation group were significantly higher than those in the control group(P<0.05).After treatment,the levels of BUN and Scr in both groups decreased compared to before treatment,and the BUN and Scr levels in the observation group were significantly lower than those in the control group(P<0.05).During the treatment period,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).During the follow-up period,the recurrence rate in the observation group was lower than that in the control group(P<0.05)Conclusion:Octreotide assisted omeprazole in the treatment of UGIB can improve the coagulation function of patients,achieve hemostatic effects in a short period of time,promote the recovery of gastrointestinal and renal functions,and have high safety,while reducing the risk of recurrence.
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