Predictive value of serum IL-33 and NLR levels in patients with liver disease
Objective:To investigate the predictive value of changes in serum interleukin-33(IL-33)and neutrophil-to-lymphocyte ratio(NLR)levels for the progression of severe liver disease in patients.Methods:Seventy-two patients with liver failure admitted to our hospital from June 2019 to September 2023 were selected as the critical group,72 patients with chronic hepatitis B were selected as the hepatitis group,and another 144 patients with health checkup in the same period were collected as the control group.The levels of serum IL-33,NLR,alanine aminotransferase(ALT),aspartate transaminase(AST),and total bilirubin(TBIL)were compared among the three groups of patients and patients with different prognoses,and their correlation and prognostic prediction value were analyzed.Results:The levels of serum IL-33,NLR,AST,ALT,and TBIL in the severe group were significantly higher than those in the hepatitis group and the control group(P<0.05).Serum IL-33 and NLR were positively correlated with AST,ALT,and TBIL(P<0.05).The serum IL-33 and NLR levels in patients with poor prognosis were higher than those in patients with good prognosis(P<0.05).The combined detection of serum IL-33 and NLR had a high predictive value for poor prognosis in patients.Conclusion:The levels of serum IL-33 and NLR are correlated with the severity of severe liver disease,and clinical detection of their levels is of great value for evaluating disease progression.
Interleukin-33Neutrophil-to-lymphocyte ratioSevere liver diseaseChronic hepatitis BLiver failureDisease progression
NETL
NSTL
万方数据
