Clinical effect of Yangxuenao Granule combined with Escitalopram in the treatment of post-stroke depression and its influence on serum 5-HT and NE levels
Objective:To investigate the clinical effects of Yangxuenao Granule combined with Escitalopram in the treatment of Post-stroke depression(PSD)and the effects of serum 5-Hydroxy tryptamine(5-HT)and Norepinephrine(NE)on the treatment of post-stroke depression(PSD).horizontal effect.Methods:400 patients with post-stroke depression were selected from our hospital.They were randomly divided into 2 groups with 200 cases each.The control group was given escitalopram,and the treatment group was given Yangxuenao granule.The efficacy,Hamilton depression scale(HAMD)score and Mini-mental state examination(MMSE)score,Barthel index score and serum 5-HT and NE levels of the two groups were analyzed and compared..Results:After treatment,the total effective rate of treatment group was significantly higher than that of control group(P<0.05).After treatment,HAMD scores in both groups were significantly lower than before treatment(P<0.05);And the treatment group decreased significantly(P<0.05).After treatment,MMSE score,Barthel index score and serum 5-HT and NE levels were significantly increased in both groups(P<0.05).And the degree of increase in the treatment group was greater(P<0.05).Conclusion:Yangxuenao Granule combined with Escitalopram in the treatment of PSD can improve clinical efficacy and cognitive function.
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