养血清脑颗粒联合艾司西酞普兰治疗卒中后抑郁的临床效果及对血清5-HT和NE水平影响
Clinical effect of Yangxuenao Granule combined with Escitalopram in the treatment of post-stroke depression and its influence on serum 5-HT and NE levels
李晓楠1
作者信息
- 1. 安阳市文峰区灯塔医院神经内科,河南 安阳 455000
- 折叠
摘要
目的:研究养血清脑颗粒联合艾司西酞普兰治疗卒中后抑郁(Post-stroke depression,PSD)的临床效果及对血清 5-羟色胺(5-Hydroxy tryptamine,5-HT)和去甲肾上腺素(Norepinephrine,NE)水平影响.方法:选取我院收治的卒中后抑郁患者 400 例.随机分为 2 组各 200 例.对照组给予艾司西酞普兰,治疗组在此基础上联用养血清脑颗粒.分析对比两组的疗效、汉密顿抑郁量表(Hamilton depression scale,HAMD)评分、简易精神状态检查量表(Mini-mental state examination,MMSE)评分和Barthel指数评分及血清 5-HT和NE水平.结果:治疗后,治疗组总有效率显著高于对照组(P＜0.05).治疗后,两组 HAMD 各条目评分均较治疗前显著降低(P＜0.05);并且治疗组降低程度较大(P＜0.05).治疗后,两组MMSE评分和Barthel指数评分及血清 5-HT和NE水平均显著升高(P＜0.05);且治疗组升高程度较大(P＜0.05).结论:采用养血清脑颗粒联合艾司西酞普兰治疗PSD可提高临床疗效,能够改善认知功能.
Abstract
Objective:To investigate the clinical effects of Yangxuenao Granule combined with Escitalopram in the treatment of Post-stroke depression(PSD)and the effects of serum 5-Hydroxy tryptamine(5-HT)and Norepinephrine(NE)on the treatment of post-stroke depression(PSD).horizontal effect.Methods:400 patients with post-stroke depression were selected from our hospital.They were randomly divided into 2 groups with 200 cases each.The control group was given escitalopram,and the treatment group was given Yangxuenao granule.The efficacy,Hamilton depression scale(HAMD)score and Mini-mental state examination(MMSE)score,Barthel index score and serum 5-HT and NE levels of the two groups were analyzed and compared..Results:After treatment,the total effective rate of treatment group was significantly higher than that of control group(P<0.05).After treatment,HAMD scores in both groups were significantly lower than before treatment(P<0.05);And the treatment group decreased significantly(P<0.05).After treatment,MMSE score,Barthel index score and serum 5-HT and NE levels were significantly increased in both groups(P<0.05).And the degree of increase in the treatment group was greater(P<0.05).Conclusion:Yangxuenao Granule combined with Escitalopram in the treatment of PSD can improve clinical efficacy and cognitive function.
关键词
养血清脑颗粒/艾司西酞普兰/卒中后抑郁/血清5-HT/NE水平Key words
Yangxuenao Granule/Escitalopram/Post-stroke depression/Serum 5-HT/NE level引用本文复制引用
出版年
2024
NETL
NSTL
万方数据