Research progress on the relationship between circadian rhythm disturbance and Alzheimer's disease
Alzheimer's disease(AD)is a common neurodegenerative disease.Its pathological features include β-amyloid(Aβ)deposition,neuronal death and cognitive decline.In recent years,more and more studies have shown that biological species or circadian rhythm disturbance is closely related to the occurrence and development of AD.25%to 40%of AD patients are accompanied by different degrees of recent rhythm disturbance sleep fragmentation at night,increased daytime napping and other symptoms.The results show that AD and rhythm disturbance can interact and influence through the common pathway,like the generation and clearance of Aβ,neuronal damage and death of neurons,neurofibrillary tangles caused by tau phosphorylation,inflammatory response caused by immune activation,melatonin and GSK-3β.Here,the recent research progress on the bilateral relationship between circadian rhythm disturbance and AD is reviewed,and current treatments for circadian rhythm disturbance and AD are summarized.
Alzheimer's diseaseCircadian rhythmBilateral relationshipPathways of actionTherapeutic methods
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