Clinical diagnostic value and significance of GM and IL-8 tests in invasive pulmonary aspergillosis
Objective:To explore the clinical value and significance of GM and IL-8 levels in alveolar lavage fluid in the diagnosis of invasive pulmonary aspergillosis.Methods:52 patients with pulmonary aspergillus who were hospitalized in Luoyang Central Hospital from January 2021 to April 2023 were selected as the study objects(including 10 cases in the confirmed group and 42 cases in the clinical diagnosis group).93 patients with pulmonary bacterial infection who were hospitalized during the same period were selected as control group.All hospitalized patients underwent bronchial examination before treatment,and the levels of GM and IL-8 in blood and GM and IL-8 in alveolar lavage fluid were determined,and the diagnostic efficacy was compared and analyzed.Results:The U values of serum GM,alveolar lavage fluid GM,serum IL-8 and IL-8 levels in IPA group and non-IPA group were 3448.500,1320.000,3922.000 and 3796.500,respectively,with(P<0.001),and the differences were statistically significant.When the serum GM level was 0.365,the area under the curve was 0.713(P<0.001)(95%confidence interval 0.616-0.810),the diagnostic efficiency was the highest,the sensitivity was 59.6%,and the specificity was 81.7%.When the GM level of alveolar lavage fluid was 1.0,the area under the curve was 0.728(P<0.001)(95%confidence interval 0.643～0.813),indicating the highest diagnostic efficiency,sensitivity 38.5%,specificity 96.8%.When serum IL-8 level was 55.0,the area under the curve was 0.811(P<0.001)(95%confidence interval 0.728-0.893),indicating the highest diagnostic efficacy,sensitivity 73.1%,specificity 84.9%.When the level of IL-8 in alveolar lavage fluid was 933.5,the area under the curve was 0.785(P<0.001)(95%confidence interval 0.705～0.865),indicating the highest diagnostic efficacy,sensitivity of 50%and specificity of 97.8%.Serum GM,alveolar lavage fluid GM,serum IL-8,and alveolar lavage fluid IL-8 levels were combined for diagnosis,sensitivity 90.4%,specificity 71.0%,PPV63.5%,NPV93%,and Jorden index 0.614.Conclusion:The combination of GM and IL-8 has certain clinical value in the diagnosis of IPA,which is expected to become a new diagnostic method.
NETL
NSTL
万方数据
