Analysis of positive significance of mild hypothermia therapy combined with Edaravone in delayed hypoperfusion after sTBI
Objective:To investigate the effect of mild hypothermia therapy combined with edaravone on patients with severe traumatic brain injury(sTBI)and its impact on delayed hypoperfusion.Methods:A total of 82 patients with sTBI admitted to our hospital from May 2021 to May 2023 were selected and randomly divided into two groups using a double-blind method(n=41).The control group patients were treated with edaravone 30 mg intravenously,while the observation group patients were treated with edaravone combined with mild hypothermia.After 2 weeks of continuous treatment,the National Institutes of Health Stroke Scale(NIHSS)was used to evaluate neurological function,the Mini-Mental State Examination(MMSE)was used to evaluate cognitive function,and the enzyme-linked immunosorbent assay was used to detect serum indicators.The laser Doppler cerebral blood flow meter was used to monitor cerebral blood flow parameters,and the complications were statistically analyzed.Results:Compared with before treatment,both groups showed increased MMSE scores and decreased NIHSS scores(P<0.05),with more significant improvement in the observation group(P<0.05).Compared with before treatment,both groups showed decreased serum ischemia modified albumin(IMA)and neuron-specific enolase(NSE)levels(P<0.05),with more significant improvement in the observation group(P<0.05).Compared with before treatment,both groups showed decreased pulse wave velocity(Wv)and dynamic resistance(DR),as well as increased mean cerebral blood flow(Qmean)and mean cerebral blood flow velocity(Vmean)(P<0.05),with more significant improvement in the observation group(P<0.05).The statistics of the complications in the two groups showed that the control group vs the observation group(7.32%vs 14.63%)(P>0.05).Conclusion:The use of edaravone combined with mild hypothermia therapy for sTBI patients can improve patients'cognitive function and neurological function,improve their cerebral blood flow level,and prevent the occurrence of delayed hypoperfusion.
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