IVIM-DWI多定量参数及血清lncRNA CASC9水平与肝细胞肝癌患者临床病理特征的相关性分析
Correlation analysis of multi-quantitative parameters of IVIEM-DWI and serum lncRNA CASC9 level with clinicopathological characteristics of hepatocellular carcinoma patients
李菡1
作者信息
- 1. 河南大学第一附属医院医学影像科,河南 开封 475000
- 折叠
摘要
目的:探讨体素内不相干运动-扩散加权成像(Intravoxel incoherent motion diffusion weighted imaging,IVIM-DWI)多定量参数及血清长链非编码RNA肿瘤易感候选者9(Long non-coding RNA tumor susceptibility candidate gene 9,lncRNA CASC9)水平与肝细胞肝癌(Hepatocellular carcinoma,HCC)患者临床病理特征的相关性.方法:选取 2021 年 8 月至 2023 年 8 月我院收治的 89 例HCC患者为研究对象,均行IVIM-DWI检查,并取HCC组织与癌旁组织.比较HCC组织、癌旁组织及不同临床病理特征HCC组织IVIM-DWI多定量参数:扩散系数(Diffusion coefficient,D)、假扩散系数(False diffusion coefficient,D*)、表观扩散系数(Apparent diffusion coefficient,ADC)、灌注分数(Perfusion fraction,PF)及血清lncRNA CASC9水平,分析多定量参数及血清lncRNA CASC9水平与临床病理特征之间的相关性.结果:HCC组织D、ADC水平低于癌旁组织,D*、PF、lncRNA CASC9 水平高于癌旁组织(P＜0.05);HCC组织D、ADC水平比较:无门静脉癌栓＞有门静脉癌栓,Ⅰ-Ⅱ期＞Ⅲ-Ⅳ期,中高分化＞低分化,无淋巴结转移＞有淋巴结转移,D*、PF、lncRNA CASC9 水平比较:无门静脉癌栓＜有门静脉癌栓,Ⅰ-Ⅱ期＜Ⅲ-Ⅳ期,中高分化＜低分化,无淋巴结转移＜有淋巴结转移(P＜0.05);HCC组织D、ADC水平与门静脉癌栓、TNM分期、分化程度、淋巴结转移均呈负相关,D*、PF、lncRNA CASC9水平与之均呈正相关(P＜0.05).结论:IVIM-DWI多定量参数及血清lncRNA CASC9 水平与HCC患者临床病理特征均具有一定相关性,联合应用可作用临床评估HCC病情的有效方式.
Abstract
Objective:To investigate the correlation between multi-quantitative parameters of intravoxel incoherent motion diffusion-weighted imaging(IVIEM-DWI)and serum long non-coding RNA tumor susceptibility candidate gene 9(lncRNA CASC9)levels and clinicopathological features of patients with hepatocellular carcinoma(HCC).Methods:A total of 89 HCC patients admitted to our hospital from August 2021 to August 2023 were selected as the study objects.IVIM-DWI examination was performed on all patients,and HCC tissues and adjacent tissues were taken.The multi-quantitative parameters of IVIM-DWI,including diffusion coefficient(D),false diffusion coefficient(D*),apparent diffusion coefficient(ADC),perfusion fraction(PF),and serum lncRNA CASC9 levels in HCC tissues,para-cancer tissues and HCC tissues with different clinicopathological characteristics were compared.The correlation between multi-quantitative parameters,serum lncRNA CASC9 level and clinicopathological features was analyzed.Results:The levels of D and ADC in HCC tissues were lower than those in paracancer tissues,and the levels of D*,PF,and lncRNA CASC9 were higher than those in paracancer tissues(P<0.05).Comparison of D and ADC levels in HCC tissues:no portal vein cancer thrombi>with portal vein cancer thrombi,stage Ⅰ-Ⅱ>Ⅲ-Ⅳ,medium and high differentiation>low differentiation,no lymph node metastasis>with lymph node metastasis,comparison of D*,PF and lncRNA CASC9 levels:No portal vein cancer thrombus<with portal vein cancer thrombus,stage Ⅰ-Ⅱ<Ⅲ-Ⅳ,middle and high differentiation<low differentiation,no lymph node metastasis<with lymph node metastasis(P<0.05);The levels of D and ADC in HCC tissues were negatively correlated with portal vein cancer thrombin,TNM stage,differentiation degree,and lymph node metastasis,while the levels of D*,PF and lncRNA CASC9 were positively correlated with HCC tissues(P<0.05).Conclusion:The multi-quantitative parameters of IVIEM-DWI and serum lncRNA CASC9 level are correlated with the clinicopathological characteristics of HCC patients to a certain extent,and the combined application can be an effective way to evaluate the clinical condition of HCC.
关键词
体素内不相干运动-扩散加权成像/多定量参数/长链非编码RNA肿瘤易感候选者9/肝细胞肝癌/临床病理特征Key words
Intravoxel incoherent motion diffusion weighted imaging/Multiple quantitative parameters/Long non-coding RNA tumor susceptibility candidate gene 9/Hepatocellular carcinoma/Clinicopathological features引用本文复制引用
基金项目
2022年度开封市科技发展计划项目(2203032)
出版年
2024
NETL
NSTL
万方数据