Correlation analysis of multi-quantitative parameters of IVIEM-DWI and serum lncRNA CASC9 level with clinicopathological characteristics of hepatocellular carcinoma patients
Objective:To investigate the correlation between multi-quantitative parameters of intravoxel incoherent motion diffusion-weighted imaging(IVIEM-DWI)and serum long non-coding RNA tumor susceptibility candidate gene 9(lncRNA CASC9)levels and clinicopathological features of patients with hepatocellular carcinoma(HCC).Methods:A total of 89 HCC patients admitted to our hospital from August 2021 to August 2023 were selected as the study objects.IVIM-DWI examination was performed on all patients,and HCC tissues and adjacent tissues were taken.The multi-quantitative parameters of IVIM-DWI,including diffusion coefficient(D),false diffusion coefficient(D*),apparent diffusion coefficient(ADC),perfusion fraction(PF),and serum lncRNA CASC9 levels in HCC tissues,para-cancer tissues and HCC tissues with different clinicopathological characteristics were compared.The correlation between multi-quantitative parameters,serum lncRNA CASC9 level and clinicopathological features was analyzed.Results:The levels of D and ADC in HCC tissues were lower than those in paracancer tissues,and the levels of D*,PF,and lncRNA CASC9 were higher than those in paracancer tissues(P<0.05).Comparison of D and ADC levels in HCC tissues:no portal vein cancer thrombi>with portal vein cancer thrombi,stage Ⅰ-Ⅱ>Ⅲ-Ⅳ,medium and high differentiation>low differentiation,no lymph node metastasis>with lymph node metastasis,comparison of D*,PF and lncRNA CASC9 levels:No portal vein cancer thrombus<with portal vein cancer thrombus,stage Ⅰ-Ⅱ<Ⅲ-Ⅳ,middle and high differentiation<low differentiation,no lymph node metastasis<with lymph node metastasis(P<0.05);The levels of D and ADC in HCC tissues were negatively correlated with portal vein cancer thrombin,TNM stage,differentiation degree,and lymph node metastasis,while the levels of D*,PF and lncRNA CASC9 were positively correlated with HCC tissues(P<0.05).Conclusion:The multi-quantitative parameters of IVIEM-DWI and serum lncRNA CASC9 level are correlated with the clinicopathological characteristics of HCC patients to a certain extent,and the combined application can be an effective way to evaluate the clinical condition of HCC.
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