Application of retinol binding protein determination in neonatal vitamin A supplementation
Objective:To explore the application effect of retinol binding protein(RBP)determination in neonatal vitamin A supplementation.Methods:Neonates in neonatal and premature infant wards of our hospital were selected from June 2019 to December 2023 were retrospectively selected.According to different gestational ages,neonates of 28-32 weeks were set as group A,neonates of 33-36 weeks were included in group B,and neonates of 37-42 weeks were enrolled as group C,with 40 cases in each group.Vitamin A was given daily after admission.The RBP measurement value was compared among infants with different gestational ages before vitamin A supplementation,and the relationship between RBP level and gestational age was analyzed.The change of RBP level detected by immunoturbidimetry before and after vitamin A supplementation was compared among the three groups,and the relationship with vitamin A supplementation was analyzed.Results:The level of RBP was positively correlated with gestational age(r=0.224,P<0.05).Before treatment,the level of fetal RBP in the three groups was statistically significant(P<0.05).After treatment,the level of fetal RBP in the three groups was significantly increased(P<0.05),and the change of fetal RBP level in group A was significantly higher than that in group B and group C(P<0.05).RBP level was positively correlated with vitamin A supplementation(r=0.286,P<0.05).Conclusion:There is a certain correlation between RBP level and gestational age.The determination of RBP is helpful to determine the level of vitamin A in neonates,and it can be used as the evaluation standard of clinical efficacy of vitamin A supplementation.Moreover,with a young gestational age,supplementing with vitamin A has a better effect.
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