Effects and Safety of Different Administration Frequencies of Low Molecular Weight Heparin Calcium Combined with Barometric Therapy in Preventing Postpartum DVT Formation in Elderly Pregnant Women
Objective:To observe the effects of different administration frequencies of low molecular weight heparin calcium combined with barometric therapy in preventing postpartum deep vein thrombosis(DVT)formation in women of advanced maternal age(AMA).Methods:A total of 90 AMA patients who gave birth in our hospital from January 2023 to December 2023 were selected and randomly divided into a control group,an observation group 1,and an observation group 2 using a random number table method,with 30 cases in each group.The control group received pneumatic therapy;the observation group 1 and observation group 2 received subcutaneous injections of low molecular weight heparin calcium 5000 IU once a day or once every 12 hours on top of the control group,with all mothers receiving treatment for 5 consecutive days.On the 1st,3rd,and 5th days after delivery,the levels of fibrinogen(Fbg),activated partial thromboplastin time(aPTT),prothrombin time(PT),thrombin time(TT),D2-dimer,and hemoglobin(Hb)were measured using a fully automated coagulation analyzer.Also,the levels of whole blood high shear viscosity and whole blood medium shear viscosity were measured using a hemorheology detector to evaluate hemorheology.The incidence of DVT and adverse reactions in the elderly patients were recorded after 5 days of medication.Results:On the 5th day of medication,the coagulation function-related indicators in the observation group 2 were significantly lower than those in the observation group 1 and the control group(P<0.05).The hemorheology indicators in the observation group 2 were significantly higher than those in the observation group 1 and the control group(P<0.05).On the 5th day of medication,the incidence of DVT in the observation group 2 was significantly lower than that in the control group(P<0.05),and there was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:Low molecular weight heparin calcium once every 12 hours combined with pneumatic therapy can improve coagulation function and hemorheology indicators in AMA patients,reduce the incidence of DVT,and is safe.
Deep vein thrombosisWomen of advanced maternal ageHeparin calciumBarometric therapyDifferent administration frequencies
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