Risk factors of lung injury induced by three-dimensional conformal radiotherapy in patients with stage Ⅱ-Ⅲ breast cancer
Objective:To analyze the risk factors of lung injury induced by three-dimensional conformal radiotherapy in stage Ⅱ-Ⅲ breast cancer.Methods:A total of 138 patients with stage Ⅱ-Ⅲ breast cancer who underwent three-dimensional conformal radiotherapy in the hospital were enrolled as the research objects between January 2020 and January 2022.Patients were categorized into two groups based on the presence or absence of radiation-induced lung injury(RILI)following radiotherapy:RILI group(n=30)and non-RILI group(n=108).Clinical data for all patients were collected,and Logistic regression analysis was conducted to identify the risk factors associated with RILI after three-dimensional conformal radiotherapy.Results:Significant differences were observed in age,clinical staging,Dmean,V5,V10,V15,V20,and V25 of the lateral lung between the two groups(P>0.05).Logistic regression analysis indicated that chronic obstructive pneumonia and V20 were identified as risk factors for RILI induced by three-dimensional conformal radiotherapy in patients with stage Ⅱ-Ⅲ breast cancer.Conclusion:Chronic obstructive pneumonia and V20 are established as risk factors for RILI induced by three-dimensional conformal radiotherapy in patients with stage Ⅱ-Ⅲ breast cancer.
Breast cancerThree-dimensional conformal radiotherapyRadiation-induced lung injuryRisk factor
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