Application value of dexmedetomidine awakening anesthesia in patients with glioma resection in brain function area
Objective:To investigate the effect of dexmedetomidine awakening anesthesia on patients with glioma resection in brain function area.Methods:Ninety-eight patients with glioma resection in brain function areas were selected in our department from January 2020 to December 2022,and divided into a control group receiving General anesthesia(GA)(n=49)and a control group receiving Awake anesthesia(n=49)randomly.Anesthesia quality,cerebral protective effects,cerebrospinal fluid amino acid levels,and postoperative delirium incidence were compared between the two groups.Results:The waking time of the observation group was lower than that of the control group,the waking degree and waking quality were better than those of the control group(P<0.05).After anesthesia,serum levels of S100 beta calcium binding protein(S100β)and Neuron-specific enolase(NSE)in two groups were higher than those before anesthesia induction;and their levels in observation group were lower than those in control group(P<0.05);The level of inhibitory amino acid γ-aminobutyric acid(GABA)in observation group was higher than that in control group,and the levels of excitatory amino acid aspartic acid(Asp)and Glutamate(Glu)were lower than those in control group(P<0.05).There was no statistical significance difference between the incidence of postoperative delirium in two groups.Conclusion:Dexmedetomidine can improve the quality of anesthesia in patients with glioma in cerebral functional area during arousal anesthesia surgery,and can also improve the level of amino acids in cerebrospinal fluid and brain protective effect,and reduce brain tissue injury.
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