Clinical characteristics and risk factors of prognosis in children with streptococcus bloodstream infection
Objective:To explore clinical characteristics and risk factors of prognosis in children with streptococcus bloodstream infection(BSI).Methods:A retrospective analysis was performed on clinical data of 60 children with streptococcus BSI who were confirmed in the hospital between January 2022 and December 2023.The clinical data of children were collected.According to prognosis,children were divided into poor prognosis group and good prognosis group.Univariate analysis was performed.The clinical characteristics of children in the two groups were compared.The risk factors of prognosis in children with streptococcus BSI were analyzed by Logistic regression analysis.Results:Among 60 children with streptococcus BSI,there were 12 cases with poor prognosis and 48 cases with good prognosis.The children were mainly from communities(80%).There was no significant difference in fever history,types of clinical infection or infection seasons between good prognosis group and poor prognosis group(P>0.05),but proportions of children with age>3 years and use types of antibiotics≥2 in good prognosis group were higher than those in poor prognosis group(P<0.05).There was no significant difference in hemoglobin level between good prognosis group and poor prognosis group(P>0.05).Compared with poor prognosis group,platelet level was significantly higher,number of white blood cells was more,and level of C-reactive protein was lower in good prognosis group(P<0.05).The results of Logistic regression analysis showed that increased C-reactive protein(OR=1.629,P=0.010)was an independent risk factor of poor prognosis in children with streptococcus BSI,while increased white blood cells(OR=0.584,P=0.031)and platelets(OR=0.504,P=0.038)were protective factors against poor prognosis(P<0.05).Conclusion:The manifestations are diverse in children with streptococcus BSI,and the incidence of infection is higher in those with age<6 years.Decreased white blood cells,platelets and increased C-reactive protein are independent risk factors of prognosis in children with streptococcus BSI,which should be emphatically prevented to improve prognosis of children.
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