Clinical value of insulin resistance and coagulation function testing in patients with nonalcoholic fatty liver disease
Objective:To analyze the clinical value of insulin resistance and coagulation function testing in patients with NAFLD.Methods:A retrospective analysis was performed on the clinical data of 60 patients with NAFLD admitted to the hospital from October 2020 to October 2023.The patients were included in NAFLD group,and 60 healthy individuals who received health checkups during the same period were selected as the control group.Patietns in NAFLD group were divided into mild group(20 cases),moderate group(22 cases)and severe group(18 cases)according to the severity.Within 24 hours after admission,HOMA-IR was used to evaluate the degree of insulin resistance in both groups.PT,APTT,FIB and TT were measured using a coagulometer.Pearson analysis was performed to discuss the relationship between HOMA-IR and PT,APTT,FIB,TT in patients with NAFLD.The receiver operating characteristic(ROC)curves were plotted to evaluate the diagnostic efficacy of HOMA-IR,PT,APTT,FIB,and TT for NAFLD.Results:Compared with the control group,HOMA-IR,PT,APTT and TT in NAFLD group were higher,and FIB level in NAFLD group was lower(P<0.05).HOMA-IR,PT,APTT and TT in the severe group were higher than those in the moderate group and the mild group.FIB level was lower than those in the moderate group and the mild group.HOMA-IR,PT,APTT and TT in the moderate group were higher than those in the mild group,and FIB level was lower than that in the mild group(P<0.05).Pearson correlation analysis showed that HOMA-IR was positively correlated with PT,APTT and TT,and negatively correlated with FIB(P<0.05).ROC curves indicated that the sensitivity of HOMA-IR combined with PT,APTT,TT and FIB for diagnosing NAFLD was 91.70%,and the AUC was 0.900.Both were higher than those of diagnosis using a single indicator(P<0.05).Conclusion:Patients with NAFLD have significant insulin resistance and coagulation dysfunction,and the two are correlated.They can serve as markers for diagnosis and grading of NAFLD.
Nonalcoholic fatty liver diseaseDegree of insulin resistanceCoagulation function
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NSTL
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