目的:探讨益生菌联合小儿推拿治疗肠系膜淋巴结炎患儿的临床疗效,分析其对腹痛程度、T淋巴细胞亚群水平的影响.方法:选取2021年1月～2022年12月本院收治的120例肠系膜淋巴结炎患儿作为研究对象,随机分为单一组与联合组,各60 例.单一组采用小儿推拿治疗,联合组在单一组基础上增加益生菌治疗.对比两组临床疗效、临床症状消失时间及治疗前后腹痛程度、炎性因子、T淋巴细胞亚群(CD3+、CD4+)水平和CD4+/CD8+比值.结果:联合组总有效率明显高于单一组(P＜0.05);联合组临床症状消失时间均明显较单一组缩短(P＜0.05).治疗后,联合组视觉模拟评分法(Visual analog scales,VAS)评分、胃泌素(Gastrin,GAS)、胃动素(Motilin,MIL)水平、肠杆菌、葡萄球菌、血清白细胞介素-6(Interleutin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)水平均明显低于单一组(P＜0.05),肠系膜淋巴结横径、纵径小于单一组(P＜0.05);联合组血管活性肠肽(Vasoactive intestinal peptide,VIP)水平及乳杆菌、双歧杆菌、CD3+、CD4+、CD4+/CD8+均明显高于单一组(P＜0.05).结论:益生菌联合小儿推拿治疗肠系膜淋巴结炎患儿的疗效显著,可减轻腹痛程度,加快病情康复进程,缩小肠系膜淋巴结,并可改善消化功能,减轻炎性反应,纠正T淋巴细胞亚群紊乱状态.
Effect of probiotics combined with pediatric massage on the degree of abdominal pain and T lymphocyte subsets in children with mesenteric lymphadenitis
Objective:To investigate the clinical efficacy of probiotics combined with pediatric massage in the treatment of children with mesenteric lymphadenitis,and analyze the effects on the degree of abdominal pain and the level of T lymphocyte subsets.Methods:A total of 120 children with mesenteric lymphadenitis admitted to our hospital from January 2021 to December 2022 were selected as the research subjects and randomly divided into a single group and a combined group,with 60 cases in each group.The single group was treated with pediatric massage therapy,while the combined group was treated with probiotics on the basis of the single group.The clinical efficacy,duration of clinical symptoms,degree of abdominal pain before and after treatment[visual analogue scale(VAS)],size of mesenteric lymph nodes,digestive function[gastrin(GAS),motilin(MIL),vasoactive intestinal peptide(VIP),enterobacter,staphylococcus,Lactobacillus,bifidobacterium],inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)],T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+)levels,and CD4+/CD8+ratio were compared between the two groups.Results:The total effective rate of combined group was significantly higher than that of single group(P<0.05).The time to disappearance of clinical symptoms was significantly shorter in the combined group than in the single group.(P<0.05).The Visual analog scales(VAS)scores,gastrin(GAS),motilin(MIL)levels,Enterobacteriaceae,staphylococci,serum interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)levels in the combined group were significantly lower than those in the single group,and the transverse and longitudinal diameter of mesenteric lymph nodes were lower than that of single group(P<0.05).Vasoactive intestinal peptide(VIP)levels and Lactobacillus,Bifidobacterium,CD3+,CD4+,CD4+/CD8+were significantly higher in the combined group than in the single group(P<0.05).Conclusion:Probiotics combined with massage therapy for children with mesenteric lymphadenitis has a significant effect,which can reduce the degree of abdominal pain,accelerate the process of rehabilitation,shrink mesenteric lymph nodes,improve digestive function,reduce inflammatory response,and correct the disorder of T lymphocyte subgroups.
Mesenteric lymphadenitisProbioticsMassage for childrenCurative effectT lymphocyte subsets
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