Analysis of the application value of HBV DNA load detection in hepatitis B pregnant women in mother to child transmission
Objective:To analyze the application value of hepatitis B virus(HBV)Deoxyribonucleic acid(DNA)load detection in mother to child transmission in pregnant women with hepatitis B.Methods:100 pregnant women with hepatitis B from January 2021 to January 2022 were selected for the study.According to the results of two pairs of semi qualitative tests of hepatitis B B in pregnant women,they were divided into large three positive groups,small three positive groups,and other groups.The detection results of HBV DNA load in umbilical cord blood of pregnant women in each group and the positive rate of HBV DNA in newborns after one year were compared;Compare the HBV-DNA load test results of umbilical cord blood from pregnant women and newborns with different HBV-DNA loads.Results:Among the 100 pregnant women,there were 46 cases(46.00%)with high triple positive,32 cases(32.00%)with low triple positive,and 22 cases(22.00%)with low triple positive.Among 100 pregnant women,14 newborns had positive HBV-DNA in umbilical cord blood,and the incidence of intrauterine infection was 14.00%.The positive rate of HBV-DNA in umbilical cord blood of newborns in the large three positive group was significantly higher than that in the small three positive group and other groups(P<0.05);There was no significant difference in the positive rate of HBV DNA in newborns among the three groups after 1 year(P>0.05);Among 100 pregnant women,HBV-DNA load≥10537 cases(37.00%),103-10544 cases(44.00%),and<10319 cases(19.00%).The positive rate of HBV-DNA in umbilical cord blood of newborns with a HBV-DNA load≥105 was significantly higher than that of newborns with a HBV-DNA load of 103-105 and<103(P<0.05);The average HBV-DNAlog virus load in umbilical cord blood of newborns with HBV-DNA load≥105 was significantly higher than that of 103-105(P<0.05).Conclusion:The detection of HBV DNA load in pregnant women with hepatitis B is of great significance for mother to child transmission.The detection is helpful to evaluate the infection degree of pregnant women,predict the risk of infant infection,and monitor the treatment effect.It is worth popularizing and applying.
Hepatitis BPregnant womenMaternal to child transmissionhepatitis B virus
NETL
NSTL
万方数据
