Effects of risperidone on cognitive function and metabolic status in schizophrenia patients with positive family history
Objective:To observe the effects of risperidone on cognitive function and metabolic status in schizophrenia patients with positive family history.Methods:A total of 72 schizophrenia patients(at least one relative of the two lineages and three generations had schizophrenia)were selected and assigned to the control group and the observation group(n=36)using the random number table method.The control group was treated with olanzapine(initial dose of 10 mg·d-1,once·d-1,adjusted to 10-20 mg·d-1 according to the patient's condition after 2 weeks),while the observation group was treated with risperidone(initial dose of 1 mg·d-1,once·d-1,adjusted to 2-6 mg·d-1 according to the patient's condition after 2 weeks)for 3 months.Before treatment and 3 months after treatment,the severity of schizophrenia symptoms was evaluated using the Positive and Negative Symptom Scale(PANSS),and cognitive function was evaluated using the Schizophrenia Cognition Rating Scale(SCoRS).Also,the changes in glucose and lipid metabolism indicators were detected Using a fully automated biochemical analyzer.And the adverse reactions were recorded.Results:After 3 months of treatment,both groups showed improvement in schizophrenia symptoms and cognitive function,and the observation group showed better results(P<0.05).However,there was no intergroup difference in glucose and lipid metabolism indicators and adverse reactions(P>0.05).Conclusion:Risperidone can improve the symptoms,cognitive function,and metabolic status of schizophrenia in patients with positive family history,and has good safety.
SchizophreniaPositive family historyRisperidoneCognitive functionMetabolic status
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