Effects and safety of oral and intravenous tranexamic acid in primary total hip and knee arthroplasty
Objective:To explore the efficacy and safety of oral and intravenous administration of tranexamic acid in primary total hip and knee replacement.Methods:A total of 136 patients with primary total hip and knee arthroplasty admitted to our hospital from November 2022 to November 2023 were randomly divided into the control group and the study group,with 68 cases in each group.The control group was given 1.0 g intravenous tranexamic acid treatment,and the study group was given 2.0 g oral tranexamic acid treatment.Blood loss before and 3 days after treatment was observed and recorded in the two groups,and the levels of coagulation function,inflammatory factors,and vascular endothelial function indexes were measured by automatic coagulation analyzer and enzyme-linked immunosorbent assay before and 3 days after treatment,and the clinical effects were analyzed.Results:After treatment,compared with the control group,the study group had slightly lower levels of bleeding volume,prothrombin time(PT),activated partial thromboplastin time(APTT),soluble thrombomodulin(sTM),E-selectin,and vascular endothelial growth factor(VEGF)(P>0.05).Fibrinogen(FIB)levels,C-reactive protein(CRP),interleukin-6(IL-6)levels,and overall treatment efficacy were slightly higher(P>0.05).The incidence of complications in the study group was lower than that in the control group(P<0.05).Conclusion:Both oral and intravenous tranexamic acid have significant therapeutic effects in primary total hip and knee replacement,but oral tranexamic acid is safer and worthy of promotion.
Oral administrationIntravenous injectionAminomethylcyclopentanoic acidPrimary total hip jointKnee joint replacement surgery
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维普
